{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:12:21Z","timestamp":1789855941072,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T00:00:00Z","timestamp":1229299200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>African trypanosomiases are parasitic diseases transmitted by tse\u2010tse flies, considered as the main sanitary obstacle to animal production development in sub\u2010Saharan Africa. However, if trypanosomiases have dramatic consequences on zebu (<jats:italic>Bos indicus<\/jats:italic>) populations, they have a weaker impact on the western African taurine (<jats:italic>Bos taurus<\/jats:italic>), which is known to be naturally tolerant to trypanosome infection. Mechanisms governing this trypanotolerant trait are still poorly understood, but today, recent postgenomic biotechnologies, such as the SAGE technique (<jats:styled-content>s<\/jats:styled-content>erial <jats:styled-content>a<\/jats:styled-content>nalysis of <jats:styled-content>g<\/jats:styled-content>ene <jats:styled-content>e<\/jats:styled-content>xpression) allow us to explore the full transcriptome. Twelve SAGE libraries were constructed from two trypanotolerant animals (N'Dama and Baoul\u00e9) and one susceptible species of cattle (the Sudanese zebu) during an experimental <jats:italic>Trypanosoma congolense<\/jats:italic> infection; 43,458 different tags were obtained at several particular points during the infection (before infection, at the maximum of parasitemia, the maximum of anemia, and at the end of the experiment after value normalization). Bioinformatics analyses highlighted some interesting gene variations with respect to the trypanotolerance status of the animal.<\/jats:p>","DOI":"10.1196\/annals.1428.062","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T16:35:06Z","timestamp":1250008506000},"page":"71-76","source":"Crossref","is-referenced-by-count":11,"title":["Study of Bovine Trypanotolerance by Whole Transcriptome Analysis"],"prefix":"10.1196","volume":"1149","author":[{"given":"David","family":"Berthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Chantal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Thevenon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassane","family":"Sakande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Charles","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria","family":"Bengaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Piquemal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Marti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Cuny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.20506\/rst.17.1.1088","article-title":"Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomosis","volume":"17","author":"D'Ieteren G.D.M.","year":"1998","journal-title":"Rev. Sci. Techn. Off. Int. Epiz."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb00828.x"},{"key":"e_1_2_6_4_2","unstructured":"Authi\u00e9 E.1993.Contribution \u00e0 l'\u00e9tude des m\u00e9canismes immunologiques impliqu\u00e9s dans la trypanotol\u00e9rance des taurins d'Afrique.PhD Thesis. 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