{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:30:50Z","timestamp":1791952250941,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T00:00:00Z","timestamp":1229299200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>To evaluate the effect of <jats:italic>Lactobacillus casei<\/jats:italic> on the effectiveness of the Mexican bovine babesiosis mixed vaccine, 20 bovines were randomly allocated into four groups of five animals (I, II, III, and IV). At day \u22122 animals in groups I and II were inoculated with saline solution by intramuscular route (i.m.) and animals in groups III and IV were inoculated with <jats:italic>L. casei<\/jats:italic>. At day 0 bovines in groups I and III were inoculated i.m. with bovine normal erythrocytes and animals of groups II and IV were inoculated with the babesiosis vaccine. Twenty\u2010four days later each bovine was challenged with <jats:italic>Babesia bovis<\/jats:italic>\u2010 and <jats:italic>B. bigemina<\/jats:italic>\u2010infected erythrocytes. The average rectal temperature in groups I and III was higher (<jats:italic>P<\/jats:italic> &lt; 0.05) than that in the vaccinated groups after challenge. The average packed cell volume was lower (<jats:italic>P<\/jats:italic> &lt; 0.01) in the control groups than in the vaccinated groups. At day 10 after challenge, the average anti\u2010<jats:italic>Babesia<\/jats:italic> antibody level was higher in group IV than in group II. At day 7 after vaccination, the percentage of bovines positive to gamma interferon, as determined by real\u2010time PCR, was 20, 0, 40, and 80 for groups I, II, III, and IV, respectively. All animals in control groups (I and III) were treated against babesiosis to avoid their death because they showed signs of babesiosis. The results indicate that <jats:italic>L. casei<\/jats:italic>, inoculated 2 days before the inoculation of the Mexican bivalent bovine babesiosis vaccine, improves the vaccine's efficiency.<\/jats:p>","DOI":"10.1196\/annals.1428.071","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T16:35:06Z","timestamp":1250008506000},"page":"126-130","source":"Crossref","is-referenced-by-count":3,"title":["Enhancement of the Mexican Bovine Babesiosis Vaccine Efficacy by Using <i>Lactobacillus casei<\/i>"],"prefix":"10.1196","volume":"1149","author":[{"given":"Carlos R.","family":"Bautista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus A.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Mosqueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Falcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio V.","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"6","volume-title":"Perspectivas de control de par\u00e1sitos de importancia veterinaria","author":"Mosqueda J.J.","year":"2004"},{"key":"e_1_2_7_3_2","first-page":"453","article-title":"Role of toll\u2010like receptors in innate immunity and their implication in veterinary medicine","volume":"36","author":"Bautista Garfias C.R.","year":"2005","journal-title":"Vet. 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