{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:25:51Z","timestamp":1790555151341,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T00:00:00Z","timestamp":1229299200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>The aim of this study was to determine the frequency and type of renal lesions associated with positive titers against<jats:italic>Leptospira<\/jats:italic>sp. in a stray dog population. Three hundred fifty pairs of kidneys and an equal number of serum samples were collected from dogs captured by the dog pound of Merida, Yucatan, Mexico. Euthanasia of dogs was performed following the regulations of the Official Mexican Health Ministry (NOM\u2010033\u2010ZOO\u20101995). Serum samples were evaluated with the microscopic agglutination test, and tissue samples were processed and fixed in paraffin. After staining with hematoxylin and eosin, the frequency of renal lesions was determined and classified. As an additional evaluation, samples with interstitial nephritis were stained by the Warthin\u2013Starry method in order to observe the presence of spirochete forms that could be morphologically compatible with<jats:italic>Leptospira<\/jats:italic>spp. We found that 98% of cases presented at least one type of lesion. The main histological lesions found were mesangial proliferative glomerulonephritis (MPGN) in 63.7% (<jats:italic>n<\/jats:italic>= 223), mesangial proliferative glomerulonephritis and interstitial nephritis (MPGN+IN) in 34% (<jats:italic>n<\/jats:italic>= 119), nephrosclerosis in 0.57% (<jats:italic>n<\/jats:italic>= 2), mesangial glomerulonephritis in 0.28% (<jats:italic>n<\/jats:italic>= 1), and interstitial nephritis (IN) in 0.28% (<jats:italic>n<\/jats:italic>= 1). Thirty\u2010four percent (<jats:italic>n<\/jats:italic>= 122) of the dogs were seropositive to<jats:italic>Leptospira<\/jats:italic>sp., mainly against serovar<jats:italic>canicola<\/jats:italic>. Among dogs with IN (alone or associated with MPGN) (<jats:italic>n<\/jats:italic>= 120), 49.1% were seropositive to<jats:italic>Leptospira<\/jats:italic>sp., but only 17% of them showed spirochete forms compatible with the bacteria. A statistical association between seropositive dogs and the presence of MPGN+IN was determined (<jats:italic>P<\/jats:italic>&lt; 0.0001; odds ratio 2.7, confidence interval 1.7\u20134.5). We concluded that the frequency of renal lesions found in this study is high and<jats:italic>L. canicola<\/jats:italic>is probably the most common circulating serovar in dogs from this area. Dogs that have been in contact with<jats:italic>Leptospira<\/jats:italic>spp. have a higher risk of developing renal lesions of the type MPGN+IN.<\/jats:p>","DOI":"10.1196\/annals.1428.088","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T16:35:06Z","timestamp":1250008506000},"page":"270-274","source":"Crossref","is-referenced-by-count":18,"title":["Frequency and Type of Renal Lesions in Dogs Naturally Infected with<i>Leptospira<\/i>Species"],"prefix":"10.1196","volume":"1149","author":[{"given":"A.","family":"Ortega\u2010Pacheco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"Colin\u2010Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Guti\u00e9rrez\u2010Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jim\u00e9nez\u2010Coello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"586","article-title":"Managing leptospirosis in dogs","volume":"98","author":"Carr A.","year":"2003","journal-title":"Vet. Med."},{"key":"e_1_2_6_3_2","first-page":"499","article-title":"Leptospirosis in dogs","volume":"9","author":"Baldwin C.J.","year":"1987","journal-title":"Comp. Cont. Educ. Pract. 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