{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:29:19Z","timestamp":1782800959405,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T00:00:00Z","timestamp":1216944000000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Premature ovarian \u201cfailure\u201d (POF) is an enigmatic and heterogeneous disorder characterized by amenorrhea, hypoestrogenism, and hypergonadotropinism that occurs in women under the age of 40\u2003years. The predominant causes are different in the adolescent, and more of these causes are associated with permanent cessation of ovarian function. It would seem that the more common causes of POF in adolescents include cytogenetic abnormalities involving the X chromosome, ovarian dysfunction occurring in association with other autoimmune endocrine disturbances, and chemotherapy and\/or radiation therapy given for any of a number of malignancies. Special challenges in the adolescent beyond establishing the diagnosis include counseling the young woman and her family and discussing the possibility of future pregnancy. Lifelong therapy must be addressed as well. Any discussion of POF raises numerous unanswered questions that should be the focus of future research.<\/jats:p>","DOI":"10.1196\/annals.1429.000","type":"journal-article","created":{"date-parts":[[2008,6,23]],"date-time":"2008-06-23T22:08:18Z","timestamp":1214258898000},"page":"138-145","source":"Crossref","is-referenced-by-count":34,"title":["<i>Premature Ovarian \u201cFailure\u201d in the Adolescent<\/i>"],"prefix":"10.1111","volume":"1135","author":[{"given":"Robert W.","family":"Rebar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0002-9378(16)33850-9","article-title":"Gonadotropins in women with amenorrhea: the use of plasma follicle\u2010stimulating hormone to differentiate women with and without ovarian follicles","volume":"116","author":"Goldenberg R.L.","year":"1973","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-45-4-673"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)45973-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53513-4"},{"key":"e_1_2_6_6_2","article-title":"Primary ovarian insufficiency: a more accurate term for premature ovarian failure","author":"Welt C.K.","year":"2007","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"e_1_2_6_7_2","first-page":"604","article-title":"Incidence of premature ovarian failure","volume":"67","author":"Coulam C.B.","year":"1986","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90402-1"},{"key":"e_1_2_6_9_2","first-page":"9","article-title":"Premature ovarian failure","volume":"66","author":"Aiman J.","year":"1985","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991229)89:4<186::AID-AJMG3>3.0.CO;2-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091550309"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707163170301"},{"key":"e_1_2_6_13_2","first-page":"70s","article-title":"Triple\u2010X syndrome and premature ovarian failure","volume":"62","author":"Villanueva A.L.","year":"1983","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi012"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/422103"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-28-1-79"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)91053-2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1988.tb00180.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/01971529108053274"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.1.107"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03205-3"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.8.2096"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1985"},{"key":"e_1_2_6_24_2","first-page":"99","article-title":"Autoimmunity in premature ovarian failure","volume":"36","author":"Muechler E.K.","year":"1991","journal-title":"Int. J. Fertil."},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-107-6-2130"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-1-120"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-6-1221"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02661.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1967.tb15424.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod32.5.1127"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7027442"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod16.2.216"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197605202942102"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198206000-00008"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)49268-X"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-53-628-271"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1148\/32.5.538"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00155-1"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.38"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.11.059"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369443-0\/50010-7"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.3109\/01674820009075624"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142505"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(71)90927-6"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90690-3"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000291503"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1159\/000291817"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.5.483"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.08.086"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198742060-00002"},{"key":"e_1_2_6_51_2","first-page":"125","article-title":"Oocyte donation for women who have ovarian failure","volume":"1989","author":"Sauer M.V.","year":"1989","journal-title":"Contemp. Obstet. Gynecol."},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58034-0"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.01.008"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1429.000","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1429.000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T07:02:47Z","timestamp":1695625367000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1429.000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1196\/annals.1429.000"],"URL":"https:\/\/doi.org\/10.1196\/annals.1429.000","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}