{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:40:41Z","timestamp":1790361641601,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T00:00:00Z","timestamp":1216944000000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Adolescent females who have irregular menstrual periods may have the nonclassical form of congenital adrenal hyperplasia due to a mild deficiency of steroid 21\u2010hydroxylase (NC 21\u2010OHD). Hyperandrogenic signs such as acne, frontal hair loss, hirsutism, and irregular menstrual periods should alert the physician to the diagnosis of NC 21\u2010OHD. An ACTH stimulation test in which serum hormone concentrations of 17\u2010OHP, \u0394<jats:sup>4<\/jats:sup>\u2010androstenedione, and testosterone are determined will assist in the diagnosis of NC 21\u2010OHD, but the definitive diagnostic test is an analysis of the mutations in the CYP21A2 gene. Typical mutations in the CYP21A2 gene in patients with NC 21\u2010OHD are an exon 7 or an exon 1 mutation. Once the genotype establishes the diagnosis of NC 21\u2010OHD, treatment should be initiated. Typical treatment is dexamethasone, 0.25\u2003mg HS, which generally reverses the hyperandrogenic signs.<\/jats:p>","DOI":"10.1196\/annals.1429.021","type":"journal-article","created":{"date-parts":[[2008,6,23]],"date-time":"2008-06-23T22:08:18Z","timestamp":1214258898000},"page":"95-98","source":"Crossref","is-referenced-by-count":34,"title":["<i>Congenital Adrenal Hyperplasia in Adolescents<\/i>"],"prefix":"10.1111","volume":"1135","author":[{"given":"Karen","family":"Lin\u2010Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Nimkarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"New","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,25]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"866","article-title":"Worldwide experience in newborn screening for classical congenital adrenal hyperplasia due to 21\u2010hydroxylase deficiency","volume":"81","author":"Pang S.Y.","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_9_3_2","first-page":"650","article-title":"High frequency of nonclassical steroid 21\u2010hydroxylase deficiency","volume":"37","author":"Speiser P.W.","year":"1985","journal-title":"Am. 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