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This study examines the cardiac effects occurring after chronic administration of methamphetamine and parkinsonism\u2010inducing neurotoxin 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine. Despite the similarities concerning the nigrostriatal dopamine denervation, methamphetamine failed to produce chronic norepinephrine depletion in the heart, thus contrasting with what occurs in Parkinson's disease or after administration of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine. These data suggest that the chronic cardiovascular effects induced by methamphetamine rely on biochemical changes which differ from those activated by 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine or during the course of Parkinson's disease.<\/jats:p>","DOI":"10.1196\/annals.1432.017","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T11:47:03Z","timestamp":1249991223000},"page":"337-344","source":"Crossref","is-referenced-by-count":8,"title":["Methamphetamine Fails to Alter the Noradrenergic Integrity of the Heart"],"prefix":"10.1196","volume":"1139","author":[{"given":"Riccardo","family":"Ruffoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Soldani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Pasquali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ruggieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Paparelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fornai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-06-02135.2002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(79)90006-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823561"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01485901"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007758"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.5.413"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320510"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.337"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.12.1724"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90345-O"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90489-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90534-7"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00313-A"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/neur.1996.0032"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-3565(24)37011-9","article-title":"Effects of noradrenergic lesions on MPTP\/MPP+ kinetics and MPTP\u2010induced nigrostriatal dopamine depletions","volume":"283","author":"Fornai F.","year":"1997","journal-title":"J. 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