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These reactions give rise to specific markers that have been analyzed in different neurodegenerative diseases sharing protein aggregation, such as Alzheimer's disease, Pick's disease, Parkinson's disease, dementia with Lewy bodies, Creutzfeldt\u2010Jakob disease, and amyotrophic lateral sclerosis. Collectively, available data demonstrate that oxidative stress homeostasis, mitochondrial function, and energy metabolism are key factors in determining the disease\u2010specific pattern of protein molecular damage. In addition, these findings suggest the lack of a \u201cgold marker of oxidative stress,\u201d and, consequently, they strengthen the need for a molecular dissection of the nonenzymatic reactions underlying neurodegenerative processes.<\/jats:p>","DOI":"10.1196\/annals.1433.014","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T17:49:01Z","timestamp":1209577741000},"page":"315-319","source":"Crossref","is-referenced-by-count":15,"title":["<i>Maillard Reaction versus Other Nonenzymatic Modifications in Neurodegenerative Processes<\/i>"],"prefix":"10.1111","volume":"1126","author":[{"given":"Reinald","family":"Pamplona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Ilieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Josep","family":"Bellmunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cacabelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Dalfo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidre","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Portero\u2010Otin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.582"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-003-0017-9"},{"key":"e_1_2_6_4_2","first-page":"91","volume-title":"Recent Research Developments in Pathological Biochemistry. 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