{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:22:22Z","timestamp":1770481342929,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T00:00:00Z","timestamp":1208908800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>Advanced glycation endproducts (AGEs) and oxidative stress (OS) contribute to the development and progression of diabetic complications. We have reported that dietary AGEs and OS induce acute endothelial dysfunction <jats:italic>in vivo<\/jats:italic>, but little is known about their effects on adipokines. Twenty inpatients with type 2 diabetes mellitus (mean age: 55.9; range: 32\u201371\u2003years), received a standard diabetes diet for 6\u2003days. On days 4 and 6, the acute effects of a high\u2010AGE (HAGE) or a low\u2010AGE (LAGE) meal (15.100 vs. 2.750 kU AGE) were studied in a randomized, cross\u2010over, investigator\u2010blinded design. Measurements were performed after an overnight fast, at baseline (B) and at 2, 4, and 6\u2003h after the HAGE or LAGE meals. Both meals had the same ingredients and differed only by the cooking method. Two h following HAGE, a significant decrease from baseline occurred in adiponectin (\u221210%*\u2021 vs. +0%) and leptin (\u221222%*\u2021 vs. \u221213%*), and a significant increase occurred in vascular cell adhesion molecule 1 (+19%*\u2021 vs. \u22125%) and thiobarbituric acid reactive substances (+23%*\u2021 vs. +6%). These changes did not occur, or occurred to a lesser extent, following LAGE. At 4\u2003h following HAGE, an increase in methylglyoxal (+20%\u2021 vs. \u22125%) and E\u2010selectin (+54%*\u2021 vs. \u22123%) occurred. Urinary AGEs increased only after HAGE (+51%*\u2021 vs. \u22122%; values presented as HAGE vs. LAGE; *P\u2003&lt;\u20030.05 vs. baseline, \u2021P\u2003&lt;\u20030.05 vs. LAGE). The postprandial excursions in glucose, insulin, and triglycerides were similar between both meals. A meal rich in AGEs induces acute endothelial and adipocyte dysfunction. These effects were prevented by changing the cooking method.<\/jats:p>","DOI":"10.1196\/annals.1433.042","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T17:49:01Z","timestamp":1209577741000},"page":"276-279","source":"Crossref","is-referenced-by-count":47,"title":["<i>Dietary Advanced Glycation Endproducts and Oxidative Stress<\/i>"],"prefix":"10.1111","volume":"1126","author":[{"given":"Alin","family":"Stirban","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Negrean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"G\u00f6tting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Uribarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gawlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Stratmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Kleesiek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodor","family":"Koschinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Vlassara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diethelm","family":"Tschoepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.1.1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/107602960100700404"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0531"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027569.76671.A8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.1978"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.023"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0302"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2004.05.214"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.12.6474"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-004-0008-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.10.015"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.5.1236"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0320"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01588.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.726"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1433.042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1433.042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T12:58:38Z","timestamp":1695646718000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1433.042"}},"subtitle":["<scp>In Vivo<\/scp><i>Effects on Endothelial Function and Adipokines<\/i>"],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1196\/annals.1433.042"],"URL":"https:\/\/doi.org\/10.1196\/annals.1433.042","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}