{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:08:46Z","timestamp":1790845726275,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":1396,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Academic Emergency Medicine"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:bold>Objectives:<\/jats:bold> To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis. <jats:bold>Methods:<\/jats:bold>This was a single arm study, with historical controls. Hemoglobin SS or Hemoglobin S<jats:italic>\u03b2<\/jats:italic>\u00b0 children admitted for pain crisis were eligible. Two sequential treatment protocols of IV magnesium sulfate were added to standard inpatient therapy of IV fluids, opioids, and nonsteroidal anti\u2010inflammatory drugs. The initial 12 children received 40 mg\/kg (maximum of 1.5 g) of IV magnesium in the emergency department (ED), and eight and 16 hours later. Seven subsequent children received 40 mg\/kg (maximum of 2.5 g) of IV magnesium in the ED, and every eight hours for up to four inpatient days. The main outcome measure was LOS, measured in days. Differences in LOS were analyzed between the admission with magnesium, and the two previous admissions meeting the same criteria, using a Wilcoxon signed\u2010rank test for nonparametric paired data. <jats:bold>Results:<\/jats:bold> Nineteen children were enrolled. The results of the two protocols were combined for the analysis. A shorter LOS was found on study admissions (median LOS, 3.0 days compared with 5.0 and 4.0 days for the previous two admissions; p = 0.006). <jats:bold>Conclusions:<\/jats:bold> IV magnesium appears to decrease the LOS for children with sickle cell pain crisis.<\/jats:p>","DOI":"10.1197\/j.aem.2004.04.009","type":"journal-article","created":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T07:17:27Z","timestamp":1094541447000},"page":"968-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Effect of Magnesium on Length of Stay for Pediatric Sickle Cell Pain Crisis"],"prefix":"10.1111","volume":"11","author":[{"given":"David C.","family":"Brousseau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Paul","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A.","family":"Hillery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Panepinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403173301101"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.17.2099"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1136"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1584"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.3.R628"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119713"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1182\/blood.V70.6.1810.1810","article-title":"Inhibition of K transport by divalent cations in sickle erythrocytes.","volume":"70","author":"Brugnara C","year":"1987","journal-title":"Blood."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01861.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.111060"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.10.979"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02040.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1182\/blood.V87.11.4879.bloodjournal87114879","article-title":"Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin.","volume":"87","author":"Hillery CA","year":"1996","journal-title":"Blood."},{"key":"e_1_2_1_14_1","first-page":"186a","article-title":"Seasonal variation in hospital length of stay in children with sickle cell disease.","volume":"100","author":"Panepinto J","year":"2002","journal-title":"Blood."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(59)92002-1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.13.2.99"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5403.226"}],"container-title":["Academic Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1197%2Fj.aem.2004.04.009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1197\/j.aem.2004.04.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:57:48Z","timestamp":1700251068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1197\/j.aem.2004.04.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":16,"aliases":["10.1111\/j.1553-2712.2004.tb00791.x"],"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1197\/j.aem.2004.04.009"],"URL":"https:\/\/doi.org\/10.1197\/j.aem.2004.04.009","archive":["Portico"],"relation":{},"ISSN":["1069-6563","1553-2712"],"issn-type":[{"value":"1069-6563","type":"print"},{"value":"1553-2712","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"2008-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}