{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:39:04Z","timestamp":1793126344351,"version":"4.5.0"},"reference-count":24,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Clin Cancer Inform"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Artificial intelligence (AI) tools that identify pathologic features from digitized whole-slide images (WSIs) of prostate cancer (CaP) generate data to predict outcomes. The objective of this study was to evaluate the clinical validity of an AI-enabled prognostic test, PATHOMIQ_PRAD, using a clinical cohort from the Cleveland Clinic.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>We conducted a retrospective analysis of PATHOMIQ_PRAD using CaP WSIs from patients who underwent radical prostatectomy (RP) between 2009 and 2022 and did not receive adjuvant therapy. Patients also had Decipher genomic testing available. WSIs were deidentified, anonymized, and outcomes were blinded. Patients were stratified into high-risk and low-risk categories on the basis of predetermined thresholds for PATHOMIQ_PRAD scores (0.45 for biochemical recurrence [BCR] and 0.55 for distant metastasis [DM]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              The study included 344 patients who underwent RP with a median follow-up of 4.3 years. Both PathomIQ and Decipher scores were associated with rates of biochemical recurrence-free survival (BCRFS; PathomIQ score &gt;0.45\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              \u22640.45,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;.001; Decipher score &gt;0.6\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              \u22640.6,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .002). There were 16 patients who had DM, and 15 were in the high-risk PathomIQ group (Mets Score &gt;0.55). Both PathomIQ and Decipher scores were associated with rates of metastasis-free survival (PathomIQ score &gt;0.55\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              \u22640.55,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;.001; Decipher score &gt;0.6\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              \u22640.6,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .0052). Despite the low event rates for metastasis, multivariable regression demonstrated that high PathomIQ score was significantly associated with DM (&gt;0.55\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              \u22640.55, hazard ratio, 10.10 [95% CI, 1.28 to 76.92],\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .0284).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>These findings independently validate PATHOMIQ_PRAD as a reliable predictor of clinical risk in the postprostatectomy setting. PATHOMIQ_PRAD therefore merits prospective evaluation as a risk stratification tool to select patients for adjuvant or early salvage interventions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/cci-24-00292","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T20:00:20Z","timestamp":1750276820000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Artificial Intelligence\u2013Based Digital Histologic Classifier for Prostate Cancer Risk Stratification: Independent Blinded Validation in Patients Treated With Radical Prostatectomy"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-931X","authenticated-orcid":true,"given":"Magdalena","family":"Fay","sequence":"first","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-3767","authenticated-orcid":true,"given":"Ross S.","family":"Liao","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-1948","authenticated-orcid":true,"given":"Zaeem M.","family":"Lone","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-8744","authenticated-orcid":true,"given":"Chandana A.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Muhammad","sequence":"additional","affiliation":[{"name":"PathomIQ Inc, Cupertino, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chensu","family":"Xie","sequence":"additional","affiliation":[{"name":"PathomIQ Inc, Cupertino, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag","family":"Jain","sequence":"additional","affiliation":[{"name":"PathomIQ Inc, Cupertino, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-4188","authenticated-orcid":true,"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"PathomIQ Inc, Cupertino, CA"},{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-8008","authenticated-orcid":true,"given":"Hirak S.","family":"Basu","sequence":"additional","affiliation":[{"name":"PathomIQ Inc, Cupertino, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-523X","authenticated-orcid":true,"given":"Sujit S.","family":"Nair","sequence":"additional","affiliation":[{"name":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimple","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-1460","authenticated-orcid":true,"given":"Sean R.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Robert J. Tomisch Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-503X","authenticated-orcid":true,"given":"Shilpa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Weight","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Roy","sequence":"additional","affiliation":[{"name":"PathomIQ Inc, Cupertino, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5775-5293","authenticated-orcid":true,"given":"George","family":"Wilding","sequence":"additional","affiliation":[{"name":"PathomIQ Inc, Cupertino, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh K.","family":"Tewari","sequence":"additional","affiliation":[{"name":"Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-0698","authenticated-orcid":true,"given":"Eric A.","family":"Klein","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-8120","authenticated-orcid":true,"given":"Omar Y.","family":"Mian","sequence":"additional","affiliation":[{"name":"Human Biology and Radiation Oncology, Fred Hutchinson Cancer Center, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.008"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00794-x"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0508-1"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0551-y"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02641"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07894-z"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2024.01.004"},{"key":"e_1_3_7_9_2","article-title":"A novel artificial intelligence\u2013powered tool for precise risk stratification of prostate cancer progression in patients with clinical intermediate risk","author":"Nair SS","unstructured":"Nair SS, Muhammad H, Jain P, et al: A novel artificial intelligence\u2013powered tool for precise risk stratification of prostate cancer progression in patients with clinical intermediate risk. 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