{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:44:26Z","timestamp":1763415866560,"version":"3.45.0"},"reference-count":24,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Clin Cancer Inform"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Direct pediatric information to inform chemotherapy emetogenicity in pediatric patients is limited. Therefore, the framework for antiemetic selection is uncertain. This study classified the acute emetogenicity of chemotherapy regimens in pediatric patients using data extracted from the electronic health record (EHR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This retrospective, single-institution study extracted data from the EHR of patients age 0 to 18 years who received chemotherapy during an inpatient admission from July 1, 2018, through February 29, 2024. Data were organized by patient and chemotherapy block including patient demographics; date, time, and route of chemotherapy and antiemetic administration; and date and time of vomiting. When at least 30 patients received the same chemotherapy and antiemetics during a chemotherapy block, the proportion of chemotherapy blocks where patients experienced complete, partial, or failed chemotherapy-induced vomiting control was determined. Chemotherapy regimen emetogenicity was assigned using a revision of an accepted pediatric chemotherapy emetogenicity classification framework that adjusted for antiemetic administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Seven thousand two hundred ninety-six chemotherapy blocks in 1,386 patients were identified. The emetogenicity of 25 chemotherapy regimens was classified: highly (7), moderately (5), low (10), and minimally (3) emetogenic. For 19 of these, no direct pediatric information was previously available. In five, our findings confirm the previous pediatric emetogenicity classification. Relative to emetogenicity classifications for adults, our findings led to classifications that were higher (seven regimens), lower (one regimen), or the same (four regimens).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>We have applied a novel method, EHR data extraction, to provide direct pediatric evidence to classify chemotherapy emetogenicity. Increasing the certainty of chemotherapy emetogenicity facilitates effective antiemetic selection for pediatric patients. This method may be applied in multi-institution studies to increase the number of chemotherapy regimens whose emetogenicity is classified using direct pediatric evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/cci-25-00140","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:00:27Z","timestamp":1763413227000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Using Real-World Data to Determine Acute Chemotherapy Emetogenicity in Pediatric Patients"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-1061","authenticated-orcid":true,"given":"L. Lee","family":"Dupuis","sequence":"first","affiliation":[{"name":"Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Department of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrence","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Yi","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-3091","authenticated-orcid":true,"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Division of Haematology\/Oncology, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-6129","authenticated-orcid":true,"given":"Mina","family":"Tadrous","sequence":"additional","affiliation":[{"name":"Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada"},{"name":"Women's College Hospital Research and Innovation Institute, Women's College Hospital, Toronto, ON, Canada"},{"name":"Institute for Clinical Evaluative Services, Toronto, ON, Canada"},{"name":"Ontario Drug Policy Research Network, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-0083","authenticated-orcid":true,"given":"Cherry","family":"Chu","sequence":"additional","affiliation":[{"name":"Women's College Hospital Research and Innovation Institute, Women's College Hospital, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1493-9"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.02.012"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3866-6"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30001"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01296"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27646"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31295"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31372"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.55976\/jdh.120221423-18"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21586"},{"key":"e_1_3_7_12_2","unstructured":"Lo T: Using real world data to determine chemotherapy emetogenicity in pediatric oncology patients: A feasibility study. 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