{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:12:37Z","timestamp":1790907157208,"version":"4.1.0"},"reference-count":27,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Clin Cancer Inform"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>To address incomplete and inconsistent classification of pancreatic cancer resectability according to International Association of Pancreatology (IAP) anatomic, biologic, and conditional criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS<\/jats:title>\n                    <jats:p>\n                      We designed, implemented, and evaluated an interoperable, web-based platform that captured structured pretreatment data and performed algorithm-driven resectability classification. Linked modules supported referral to and discussion at multidisciplinary team meetings (MDTMs) at two quaternary hospitals (June 2021-February 2022) and populated downstream documentation. In a pre-post study, Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test and multivariable logistic regression (odds ratios [ORs] with 95% CI) compared data completeness (primary end point), as well as the distribution of IAP-defined resectability and treatment intent (secondary end points). In the postintervention cohort, overall survival (OS) was stratified by IAP resectability using Kaplan-Meier curves and compared using the log-rank test. Hazard ratios (HRs) with 95% CIs and log-rank statistics were calculated for individual resectability criteria using Cox models. All tests were two-sided with nominal significance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). An embedded module evaluated workflow integration and user experience.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Ninety-five patients with pancreatic cancer were referred to MDTMs during the intervention period, of whom 71 were eligible. Compared with 71 preintervention patients, the system improved documentation of tumor-vessel relationships (OR, 9.39 [95% CI, 4.43 to 21.7]), locoregional lymphadenopathy (OR, 30.5 [95% CI, 11.1 to 102]), and performance status (PS; OR, 3.34 [95% CI, 1.67 to 6.85]), reducing the number with\n                      <jats:italic toggle=\"yes\">unknown<\/jats:italic>\n                      resectability (OR, 0.10 [95% CI, 0.03 to 0.25]). PS \u2265 2 (HR, 2.16 [95% CI, 1.06 to 4.43]) and serum CA19.9 \u2265 500 U\/mL (HR, 1.94 [95% CI, 1.03 to 3.63]) were significantly associated with OS, whereas anatomic criteria were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      A synoptic intervention integrated into MDTM workflows across multiple sites improved structured data capture, reduced\n                      <jats:italic toggle=\"yes\">unknown<\/jats:italic>\n                      resectability, and highlighted the relevance of biologic and conditional criteria in addition to tumor anatomy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/cci-25-00255","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T21:00:15Z","timestamp":1767733215000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Synoptic Multidisciplinary Team Meeting Workflows to Promote Guideline-Based Classification of Resectability in Pancreatic Cancer: A Multicenter Prospective Study"],"prefix":"10.1200","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-6008","authenticated-orcid":true,"given":"William","family":"McGahan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Royal Brisbane and Women's Hospital, Herston, QLD, Australia"},{"name":"Department of General Surgery, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Saint Lucia, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Saint Lucia, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"O'Rourke","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Saint Lucia, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard Mark","family":"Smithers","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Princess Alexandra Hospital, Woolloongabba, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Saint Lucia, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-6465","authenticated-orcid":true,"given":"David","family":"Cavallucci","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Royal Brisbane and Women's Hospital, Herston, QLD, Australia"},{"name":"Faculty of Medicine, The University of Queensland, Saint Lucia, QLD, 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