{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:27:49Z","timestamp":1783024069412,"version":"3.54.6"},"reference-count":31,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Clin Cancer Inform"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Survivorship care models that extend beyond recurrence surveillance to ones that also address treatment-related symptoms are needed. Using data obtained in routine clinical care, we aimed to examine patient-reported symptom burden among adult thyroid cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Between September 2019 and September 2022, adults were electronically administered the MDASI-Thy, a patient-reported outcome measure that measures symptom severity and interference, within 7 days before their visit at a dedicated thyroid cancer survivorship clinic. The MDASI-Thy generates (1) core symptom severity, (2) thyroid-specific symptom severity, and (3) symptom interference scores, where lower is better. High alert values (HAVs) were defined for four symptoms: Distress (Upset), Pain, Sad, and Shortness of Breath. Multivariable generalized linear models examined associations of patient, cancer, and treatment factors with scores and any HAV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 1,557 thyroid cancer survivors, 864 (55.5%) responded. Respondents were a median of 5 years from diagnosis (IQR, 4-8) and predominantly female (79.1%), and most had papillary thyroid carcinoma (92.5%). Mean (standard deviation) scores were 1.20 (1.34) for core severity, 0.99 (1.26) for thyroid-specific severity, and 1.07 (1.80) for interference. Fatigue (11.5%) and Disturbed Sleep (11.3%) were the most common severe symptoms. HAVs occurred in 72 survivors (8.3%), of whom 54 (75%) had a documented plan addressing the HAV. Higher symptom burden was associated with female sex, Black race, greater comorbidity, active smoking, and total thyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Routine patient-reported symptom screening in thyroid cancer survivorship identified generally low symptom burden but meaningful variations, with a subset reporting severe symptoms, functional interference, and HAVs requiring action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/cci-26-00041","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:00:13Z","timestamp":1783022413000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Patient-Reported Symptom Burden Among Thyroid Cancer Survivors: Retrospective Cohort Study"],"prefix":"10.1200","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-5703","authenticated-orcid":true,"given":"Jason B.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"},{"name":"Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX"},{"name":"Patient-Reported Outcomes, Value, and Experience (PROVE) Center, Mass General Brigham, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-6678","authenticated-orcid":true,"given":"Thomas Szabo","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"},{"name":"Department of Surgery, Emory University School of Medicine, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny L.","family":"Rollins","sequence":"additional","affiliation":[{"name":"Advanced Practice Providers Program\u2014Survivorship, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Hyun","family":"Lee-Kim","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khavya C.","family":"Avula","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Chacko","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Peek","sequence":"additional","affiliation":[{"name":"Department of Clinical Access Revenue System, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-657X","authenticated-orcid":true,"given":"Loretta A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-9739","authenticated-orcid":true,"given":"Mark E.","family":"Zafereo","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-2841","authenticated-orcid":true,"given":"Anastasios","family":"Maniakas","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-3832","authenticated-orcid":true,"given":"Jennifer R.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3808-6378","authenticated-orcid":true,"given":"Naifa L.","family":"Busaidy","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-1811","authenticated-orcid":true,"given":"Maria E.","family":"Cabanillas","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2171-7022","authenticated-orcid":true,"given":"Luz E.","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysha","family":"Chaudhri","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Dadu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-030X","authenticated-orcid":true,"given":"Mimi I.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo Jimenez","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-5280","authenticated-orcid":true,"given":"Anita K.","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeena M.","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-5153","authenticated-orcid":true,"given":"Steven I.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-0100","authenticated-orcid":true,"given":"Steven G.","family":"Waguespack","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-0202","authenticated-orcid":true,"given":"Steven P.","family":"Weitzman","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-1005","authenticated-orcid":true,"given":"Nancy D.","family":"Perrier","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-7423","authenticated-orcid":true,"given":"Eileen H.","family":"Shinn","sequence":"additional","affiliation":[{"name":"Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-8353","authenticated-orcid":true,"given":"Michael E.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Patient Care, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhammed Amir","family":"Habra","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-8427","authenticated-orcid":true,"given":"Elizabeth G.","family":"Grubbs","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-2633","authenticated-orcid":true,"given":"Sarah B.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1804426"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70011"},{"key":"e_1_3_8_4_2","volume-title":"Key Statistics for Thyroid Cancer","unstructured":"Key Statistics for Thyroid Cancer. https:\/\/www.cancer.org\/cancer\/types\/thyroid-cancer\/about\/key-statistics.html"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae135"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2014.02.007"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4853"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0213"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2024.08.003"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33852"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2025.0149"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1721117"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.9265"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03507-y"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.19585"},{"key":"e_1_3_8_16_2","volume-title":"Cancer Survivorship Algorithms","unstructured":"Cancer Survivorship Algorithms. MD Anderson Cancer Cent. https:\/\/www.mdanderson.org\/for-physicians\/clinical-tools-resources\/clinical-practice-algorithms\/survivorship-algorithms.html"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000178809"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000890"},{"key":"e_1_3_8_19_2","first-page":"qxae038","article-title":"Selecting patient-reported outcome measures: \u201cWhat\u201d and \u201cFor Whom.\u201d","volume":"2","author":"Liu JB","year":"2024","unstructured":"Liu JB, Rothrock NE, Edelen MO: Selecting patient-reported outcome measures: \u201cWhat\u201d and \u201cFor Whom.\u201d Health Aff Sch 2:qxae038, 2024","journal-title":"Health Aff Sch"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa437"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2981-5"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2024.07.012"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.796499"},{"key":"e_1_3_8_24_2","article-title":"Mass General Brigham\u2019s patient-reported outcomes measurement system: A decade of learnings","volume":"5","author":"Liu JB","year":"2024","unstructured":"Liu JB, Kaplan RS, Bates DW, et al: Mass General Brigham\u2019s patient-reported outcomes measurement system: A decade of learnings. NEJM Catal 5, 2024","journal-title":"NEJM Catal"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2024.07.057"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooaf180"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.06.042"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000250483.85507.04"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1740774517698645"},{"key":"e_1_3_8_30_2","article-title":"PROMs: Opportunities, challenges, and unfinished business","volume":"2","author":"MacLean CH","year":"2021","unstructured":"MacLean CH, Antao VC, Fontana MA, et al: PROMs: Opportunities, challenges, and unfinished business. NEJM Catal 2, 2021","journal-title":"NEJM Catal"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocac029"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocae138"}],"container-title":["JCO Clinical Cancer Informatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/CCI-26-00041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:00:14Z","timestamp":1783022414000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/CCI-26-00041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1200\/CCI-26-00041"],"URL":"https:\/\/doi.org\/10.1200\/cci-26-00041","relation":{},"ISSN":["2473-4276"],"issn-type":[{"value":"2473-4276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2600041"}}