{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:23:05Z","timestamp":1790385785085,"version":"4.1.0"},"reference-count":70,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Clinical Cancer Informatics"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To assess the impact of chronomodulated irinotecan fluorouracil-leucovorin and oxaliplatin (chronoIFLO4) delivered at home on the daily life of patients with cancer in real time using a home-based e-Health multifunction and multiuser platform. This involved multidimensional telemonitoring of circadian rest-activity rhythm (CircAct), sleep, patient-reported outcome measures, and body weight changes (BWCs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients received chronoIFLO4 fortnightly at home. Patients completed the 19-item MD Anderson Symptom Inventory on an interactive electronic screen, weighed themselves on a dedicated scale, and continuously wore a wrist accelerometer for CircAct and sleep monitoring. Daily data were securely teletransmitted to a specific server accessible by the hospital team. The clinically relevant CircAct parameter dichotomy index I &lt; O and sleep efficiency (SE) were calculated. The dynamic patterns over time of patient-reported outcome measures, BWC, I &lt; O, and SE informed the oncology team on tolerance in real time. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The platform was installed in the home of 11 patients (48 to 72 years of age; 45% men; 27% with performance status = 0), who were instructed on its use on site. They received 26 cycles and provided 5,891 data points of 8,736 expected (67.4%). The most severe MD Anderson Symptom Inventory scores were: interference with work (mean: 5.1 of 10) or general activity (4.9), fatigue (4.9), distress (4.2), and appetite loss (3.6). Mean BWC was \u22120.9%, and mean SE remained &gt; 82%. CircAct disruption (I &lt; O \u2264 97.5%) was observed in four (15%) cycles before chronoIFLO4 start and in five (19%) cycles at day 14. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The patient-centered multidimensional telemonitoring solution implemented here was well accepted by patients receiving multidrug chemotherapy at home. Moreover, it demonstrated that chronoIFLO4 was a safe therapeutic option. Such integrated technology allows the design of innovative management approaches, ultimately improving patients\u2019 experience with chemotherapy, wellbeing, and outcomes. <\/jats:p><\/jats:sec>","DOI":"10.1200\/cci.17.00125","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T21:23:52Z","timestamp":1519334632000},"page":"1-15","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Home-Based e-Health Platform for Multidimensional Telemonitoring of Symptoms, Body Weight, Sleep, and Circadian Activity: Relevance for Chronomodulated Administration of Irinotecan, Fluorouracil-Leucovorin, and Oxaliplatin at Home\u2014Results From a Pilot Study"],"prefix":"10.1200","author":[{"given":"Pasquale","family":"Innominato","sequence":"first","affiliation":[{"name":"Pasquale Innominato, North Wales Cancer Centre, Betsi Cadwaladr University Health Board, Denbighshire; Pasquale Innominato, Sandra 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