{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:50:55Z","timestamp":1770292255146,"version":"3.49.0"},"reference-count":23,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Clin Cancer Inform"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Medication nonadherence is a persistent and costly problem across health care. Measures of medication adherence are ineffective. Methods such as self-report, prescription claims data, or smart pill bottles have been used to monitor medication adherence, but these are subject to recall bias, lack real-time feedback, and are often expensive. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> We proposed a method for monitoring medication adherence using a commercially available wearable device. Passively collected motion data were analyzed on the basis of the Movelet algorithm, a dictionary learning framework that builds person-specific chapters of movements from short frames of elemental activities within the movements. We adapted and extended the Movelet method to construct a within-patient prediction model that identifies medication-taking behaviors. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Using 15 activity features recorded from wrist-worn wearable devices of 10 patients with breast cancer on endocrine therapy, we demonstrated that medication-taking behavior can be predicted in a controlled clinical environment with a median accuracy of 85%. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> These results in a patient-specific population are exemplar of the potential to measure real-time medication adherence using a wrist-worn commercially available wearable device. <\/jats:p><\/jats:sec>","DOI":"10.1200\/cci.22.00107","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T20:59:47Z","timestamp":1703192387000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Detection of Medication Taking Using a Wrist-Worn Commercially Available Wearable Device"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-2847","authenticated-orcid":false,"given":"Amy I.","family":"Laughlin","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA"},{"name":"Orlando Health Cancer Institute, Orlando Health, Orlando, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-1305","authenticated-orcid":true,"given":"Quy","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Bryson","sequence":"additional","affiliation":[{"name":"Information Services, Penn Medicine, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Haughey","sequence":"additional","affiliation":[{"name":"Information Services, Penn Medicine, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0167-6103","authenticated-orcid":true,"given":"Rashad","family":"Abdul-Salaam","sequence":"additional","affiliation":[{"name":"Information Services, Penn Medicine, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-1768","authenticated-orcid":true,"given":"Virgilio","family":"Gonzenbach","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mridini","family":"Rudraraju","sequence":"additional","affiliation":[{"name":"Drexel University, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Eydman","sequence":"additional","affiliation":[{"name":"Information Services, Penn Medicine, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Tweed","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn J.","family":"Fala","sequence":"additional","affiliation":[{"name":"Information Services, Penn Medicine, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kash","family":"Patel","sequence":"additional","affiliation":[{"name":"Hackensack Meridian Health, Princeton, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin R.","family":"Fox","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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