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Notably, while the current approvals are for single agents in the relapsed\/refractory setting, clinical trials are now investigating combination approaches as well as incorporating cellular therapies and BsAbs into earlier lines of treatment. This article focuses on cellular therapies and BsAbs for treatment of various lymphomas, including review of completed or ongoing trials of using these platforms in earlier lines which have the potential to be practice changing in the near future.<\/jats:p>","DOI":"10.1200\/edbk-25-473302","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T19:59:12Z","timestamp":1748635152000},"source":"Crossref","is-referenced-by-count":5,"title":["Chimeric Antigen Receptor T-Cell Therapy and Bispecific Antibody Use in Earlier Lines of Treatment of Large B-Cell Lymphoma, Follicular Lymphoma, and Mantle Cell Lymphoma"],"prefix":"10.1200","volume":"45","author":[{"given":"Imran A.","family":"Nizamuddin","sequence":"first","affiliation":[{"name":"Washington University in St Louis School of Medicine, Saint Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-8474","authenticated-orcid":false,"given":"Armin","family":"Ghobadi","sequence":"additional","affiliation":[{"name":"Washington University in St Louis School of Medicine, Saint Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70235-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30177-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13463"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281461"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115304"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-769620"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.9593"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.1618"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12176"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.10.010"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020854"},{"key":"e_1_3_3_14_2","first-page":"2307","article-title":"Five-year follow-up of ZUMA-1 supports the curative potential of axicabtagene ciloleucel in refractory large B-cell lymphoma","volume":"141","author":"Neelapu SS","year":"2023","unstructured":"Neelapu SS, Jacobson CA, Ghobadi A, et al: Five-year follow-up of ZUMA-1 supports the curative potential of axicabtagene ciloleucel in refractory large B-cell lymphoma. 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