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Meanwhile, the incidence of cancer diagnoses in older adults continues to increase, especially in genitourinary (GU) cancers (prostate cancer, bladder cancer, and kidney cancer). As a result, there is increasing interest in oncology to develop treatment models and interventions to optimize care for older patients with cancer. In this article, we define frailty and review its association with clinical outcomes across the three most common GU cancers in older adults (prostate, bladder, and kidney cancer). We discuss existing professional society guidelines, consensus recommendations, and practical strategies to implement frailty screening, oncology-focused geriatric assessments, and targeted interventions to optimize vulnerabilities in GU cancers. We also discuss emerging innovations in geriatric oncology such as digital health tools and artificial intelligence.<\/jats:p>","DOI":"10.1200\/edbk-26-516010","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:59:08Z","timestamp":1771880348000},"source":"Crossref","is-referenced-by-count":3,"title":["Beyond Chronologic Age: Frailty, Geriatric Assessment, and Personalized Care for Older Adults With Genitourinary Cancer"],"prefix":"10.1200","volume":"46","author":[{"given":"Peter L.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Mass General Brigham, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Fitch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mass General Brigham, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Efstathiou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mass General Brigham, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullika","family":"Garg","sequence":"additional","affiliation":[{"name":"Departments of Urology and Population Health Sciences, Geisinger Health System, Danville, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8983"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.175"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001834"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33238"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2301292"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01789-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2001.58"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.3.M255"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaf017"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu540"},{"key":"e_1_3_2_13_2","article-title":"Geriatric assessment: ASCO Global guideline","author":"Bergerot CD","unstructured":"Bergerot CD, Temin S, Verduzco-Aguirre HC, et al: Geriatric assessment: ASCO Global guideline. 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