{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T19:03:03Z","timestamp":1780686183224,"version":"3.54.1"},"reference-count":119,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am Soc Clin Oncol Educ Book"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>This article examines persistent care gaps facing adolescents and young adults (AYAs) with sarcoma, focusing on clinical trial access, germline predisposition, and palliative care. Despite overall progress in oncology, AYAs continue to experience lower clinical trial enrollment\u2014the AYA gap\u2014particularly in rare cancers such as sarcoma, which spans pediatric and medical oncology. The creation of the National Cancer Institute's (NCI) National Clinical Trials Network (NCTN) fostered cross-group collaboration, broadened age eligibility, and streamlined trial activation. Early collaborative sarcoma trials highlighted both the promise and structural challenges of this model, and ongoing reforms aim to improve access, especially in community settings. This article also positions sarcoma as a high-yield context for germline cancer predisposition testing. Contemporary sequencing studies show that 10%-20% or more of patients with sarcoma harbor pathogenic germline variants, often undetected by family history\u2013based criteria. This supports a shift from syndrome-driven to tumor-informed genetic evaluation, particularly for AYAs who frequently fall between pediatric and adult testing frameworks. Finally, the importance of early, age-appropriate palliative care is highlighted. AYAs with sarcoma face substantial symptom burden, functional impairment, prognostic uncertainty, and psychosocial distress. Evidence suggests that integrated palliative care improves quality of life, communication, and potentially survival, yet referrals are often delayed. Together, these topics highlight the need for coordinated, developmentally informed, and biologically integrated approaches to optimize outcomes for AYAs with sarcoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/edbk-26-520036","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:59:13Z","timestamp":1780603153000},"source":"Crossref","is-referenced-by-count":0,"title":["Unique Challenges in Sarcoma Care for Adolescents and Young Adults"],"prefix":"10.1200","volume":"46","author":[{"given":"Sophie","family":"Jessop","sequence":"first","affiliation":[{"name":"Michael Rice Department of Haematology and Oncology, Women's and Children's Hospital, North Adelaide, SA, Australia"},{"name":"Lowy Cancer Research Centre, Children's Cancer Institute, Randwick, NSW, Australia"},{"name":"University of Adelaide, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Sankaran","sequence":"additional","affiliation":[{"name":"Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catrian","family":"Sotelo","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, The Hospital for Sick Children, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney D.","family":"Fullbright","sequence":"additional","affiliation":[{"name":"University of North Carolina, AYA Cancer Program, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanda R.","family":"Finnigan","sequence":"additional","affiliation":[{"name":"Clinical Investigations Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine L.","family":"Juhrmann","sequence":"additional","affiliation":[{"name":"Behavioural Sciences Unit, School of Clinical Medicine, UNSW Medicine and Health, Randwick Clinical Campus, Discipline of Paediatrics and Child Health, University of New South Wales Sydney, Kensington, NSW, Australia"},{"name":"Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia"},{"name":"Improving Palliative, Aged and Chronic Care Through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology, Ultimo, NSW, Australia"},{"name":"Palliative Nexus, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob N.","family":"Stein","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, Chapel Hill, NC"},{"name":"Division of Oncology, Department of Medicine, UNC Chapel Hill, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula M.","family":"Sansom-Daly","sequence":"additional","affiliation":[{"name":"Behavioural Sciences Unit, School of Clinical Medicine, UNSW Medicine and Health, Randwick Clinical Campus, Discipline of Paediatrics and Child Health, University of New South Wales Sydney, Kensington, NSW, Australia"},{"name":"Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia"},{"name":"Sydney Youth Cancer Service, Nelune Comprehensive Cancer Centre, Prince of Wales Hospital, Randwick, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-7955","authenticated-orcid":true,"given":"Nita L.","family":"Seibel","sequence":"additional","affiliation":[{"name":"Clinical Investigations Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Villani","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, The Hospital for Sick Children, Toronto, ON, Canada"},{"name":"Department of Pediatrics, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_3_2_2","first-page":"114","article-title":"The adolescent gap in cancer treatment","volume":"23","author":"Bleyer WA","year":"1996","unstructured":"Bleyer WA: The adolescent gap in cancer treatment. 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