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In this article, we examine key challenges and ongoing controversies in managing this breast cancer subtype, including the use of genomic assays in premenopausal women with node-positive disease, tailoring treatment in locally advanced tumors with favorable biology, and the current and emerging roles of circulating tumor DNA as a prognostic and predictive biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/edbk-26-520488","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T19:59:52Z","timestamp":1779998392000},"source":"Crossref","is-referenced-by-count":1,"title":["Navigating Treatment Decisions in Early-Stage Hormone Receptor\u2013Positive Breast Cancer"],"prefix":"10.1200","volume":"46","author":[{"given":"Eitan","family":"Amir","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Kristoff","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute at Emory University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Blaha","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Bender","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kalinsky","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute at Emory University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Cobain","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108873"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00007-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01064"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00557"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.10.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2025.105858"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/17588359231151840"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.516"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.SABCS23-GS03-06"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.01.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.504"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-022-00492-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.505"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03007"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-24-01507"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00069"},{"key":"e_1_3_2_18_2","first-page":"589","volume-title":"Breast\u2014AJCC Cancer Staging Manual","author":"Amin MB","year":"2017","unstructured":"Amin MB, Edge SB, Greene FL, et al: Breast\u2014AJCC Cancer Staging Manual. 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