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However, the clinical outcomes of patients with stage I TNBC and the benefit (or lack thereof) of (neo)adjuvant chemotherapy have not been prospectively evaluated as this population has largely been excluded from prospective randomized clinical trials. As such, management decisions for stage I TNBC are typically extrapolated from trials enrolling patients with stage II or III TNBC or based on retrospective analyses. Currently, the primary factor influencing systemic therapy decisions is the anatomic stage, without other biomarkers clinically used to guide systemic therapy. This review summarizes the existing evidence supporting current and emerging systemic therapy strategies for stage I TNBC, with a special focus on treatment de-escalation and promising biomarkers that can advance personalized treatment selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/edbk-26-520666","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T19:59:12Z","timestamp":1777060752000},"source":"Crossref","is-referenced-by-count":5,"title":["Stage I Triple-Negative Breast Cancer: Moving From One-Size-Fits-All to a Personalized Approach"],"prefix":"10.1200","volume":"46","author":[{"given":"Dame","family":"Idossa","sequence":"first","affiliation":[{"name":"Division of Oncology, Department of Oncology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve A.","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology, Department of Medicine, 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