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Our understanding of pathogenesis of the various histologic types of ovarian cancer have begun to inform changes to the strategies for management of epithelial ovarian cancer, which represent a paradigm shift not only for treatment but also for prevention, which previously had not been considered achievable. In this article, we will discuss novel attempts at the prevention of high-grade serous ovarian cancer and treatment strategies for two distinct entities in epithelial ovarian cancer: low-grade serous and clear cell ovarian carcinomas, which are relatively rare and resistant to conventional chemotherapy. <\/jats:p>","DOI":"10.1200\/edbk_158675","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T17:46:40Z","timestamp":1540835200000},"page":"e247-e257","source":"Crossref","is-referenced-by-count":10,"title":["Paradigm Shift in the Management Strategy for Epithelial Ovarian Cancer"],"prefix":"10.1200","author":[{"given":"Keiichi","family":"Fujiwara","sequence":"first","affiliation":[{"name":"From the Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Gynecology and Obstetrics, University of British Columbia, Vancouver, Canada; Division of Medical Oncology and Hematology, Bras Family 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