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Recent major advances in therapy with more effective and less toxic treatments have brought reconsideration of early therapeutic intervention in management of SMM, with the goal of reducing progression of the disease before the occurrence of end-organ damage to MM and improving survival. Key to this effort is accurate identification of patients at high risk of progression who would truly benefit from early intervention. In this review, we discuss the current definitions, risk factors, risk stratification, prognosis, and management of MGUS and SMM, as well as new emerging therapeutic options under active investigation.<\/jats:p>","DOI":"10.1200\/edbk_159010","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T13:46:40Z","timestamp":1540820800000},"page":"e400-e406","source":"Crossref","is-referenced-by-count":6,"title":["Future Directions in the Evaluation and Treatment of Precursor Plasma Cell Disorders"],"prefix":"10.1200","author":[{"given":"Salomon","family":"Manier","sequence":"first","affiliation":[{"name":"From the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karma Z.","family":"Salem","sequence":"additional","affiliation":[{"name":"From the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 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