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Finding the balance between under- and overtreating elderly patients is one of the biggest challenges specific to them as a subgroup of patients with MM. Decision making about which therapies and their dose intensity and duration should be influenced by a patient\u2019s functional status, personal preferences, disease characteristics, and ability to tolerate therapy. ASCT should be considered for all patients younger than age 80, assuming that they are not frail. The attainment of a stringent complete response and minimal residual disease negativity is associated with improved progression-free and overall survival. Again, consideration of quality of life for these patients is paramount. Although there is a growing list of tools to sort through these issues, a fully integrated approach has not yet been finely tuned, leaving additional work to be done for the treatment of elderly patients with MM. <\/jats:p>","DOI":"10.1200\/edbk_175171","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T17:53:53Z","timestamp":1540835633000},"page":"575-585","source":"Crossref","is-referenced-by-count":38,"title":["Myeloma in Elderly Patients: When Less Is More and More Is More"],"prefix":"10.1200","author":[{"given":"Ashley","family":"Rosko","sequence":"first","affiliation":[{"name":"From The Ohio State University, Columbus, OH; Memorial Sloan Kettering Cancer Center, New York, NY; University Hospital of Salamanca, Salamanca, Spain; Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Giralt","sequence":"additional","affiliation":[{"name":"From The Ohio State University, Columbus, OH; 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