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As molecular testing becomes increasingly important, preserving tissue for this purpose while rendering an accurate histologic diagnosis becomes a key consideration, particularly in advanced-stage NSCLC, in which small biopsy samples or aspirates are often the only specimen available. Next-generation sequencing panels are a powerful method of providing information relevant for both standard-of-care and investigational treatment options. However, taking advantage of the abundance of information gleaned from these panels requires careful annotation, prioritization, and reporting of molecular findings and their clinical significance. Although molecular profiling has traditionally relied on direct sampling of neoplastic tissue, blood-based diagnostics now offer the potential to provide some clinically useful information noninvasively. <\/jats:p>","DOI":"10.1200\/edbk_209089","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T18:58:19Z","timestamp":1528484299000},"page":"708-715","source":"Crossref","is-referenced-by-count":35,"title":["Precision Medicine in Non\u2013Small Cell Lung Cancer: Current Standards in Pathology and Biomarker Interpretation"],"prefix":"10.1200","author":[{"given":"Noah A.","family":"Brown","sequence":"first","affiliation":[{"name":"From the University of Michigan, Ann Arbor, MI; University of Colorado Cancer Center, Denver, CO; Dana-Farber Cancer Institute, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara L.","family":"Aisner","sequence":"additional","affiliation":[{"name":"From the University of Michigan, Ann Arbor, MI; 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