{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:33:20Z","timestamp":1792762400357,"version":"4.5.0"},"reference-count":91,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"39","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Society of Clinical Oncology Educational Book"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Observational evidence has consistently linked excess adiposity and inactivity to increased breast cancer risk and to poor outcomes in individuals diagnosed with early-stage, potentially curable breast cancer. There is less information from clinical trials testing the effect of weight management or physical activity interventions on breast cancer risk or outcomes, but a number of ongoing trials will test the impact of weight loss and other lifestyle changes after cancer diagnosis on the risk of breast cancer recurrence. Lifestyle changes have additional benefits beyond their potential to decrease primary or secondary breast cancer risk, including improvements in metabolic parameters, reduction in the risk of comorbidities such as diabetes and heart disease, improvement of physical functioning, and mitigation of side effects of cancer therapy. Despite these myriad benefits, implementation of lifestyle interventions in at-risk and survivor populations has been limited to date. This article reviews the evidence linking lifestyle factors to breast cancer risk and outcomes, discusses completed and ongoing randomized trials testing the impact of lifestyle change in primary and secondary breast cancer prevention, and reviews efforts to implement and disseminate lifestyle interventions in at-risk and breast cancer survivor populations.<\/jats:p>","DOI":"10.1200\/edbk_237423","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T10:29:36Z","timestamp":1558088976000},"page":"e22-e33","source":"Crossref","is-referenced-by-count":89,"title":["Weight Management and Physical Activity for Breast Cancer Prevention and Control"],"prefix":"10.1200","author":[{"given":"Jennifer A.","family":"Ligibel","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Basen-Engquist","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer W.","family":"Bea","sequence":"additional","affiliation":[{"name":"University of Arizona Cancer Center, Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"bibr1-EDBK_237423","volume-title":"Breast Cancer Facts & Figures 2017-2018","author":"American Cancer Society","year":"2017"},{"key":"bibr2-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu042"},{"key":"bibr3-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20140"},{"key":"bibr4-EDBK_237423","volume-title":"Diet, Nutrition, Physical Activity and Cancer: A Global Perspective. Continuous Update Project Expert Report","author":"World Cancer Research Fund\/American Institute for Cancer Research"},{"key":"bibr5-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.1548"},{"key":"bibr6-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9916-1"},{"key":"bibr7-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.6217"},{"key":"bibr8-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv179"},{"key":"bibr9-EDBK_237423","first-page":"994","volume":"25","author":"Ligibel J","year":"2011","journal-title":"Oncology (Williston Park)"},{"key":"bibr10-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-0485"},{"key":"bibr13-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.1546"},{"key":"bibr14-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.2.193"},{"key":"bibr15-EDBK_237423","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/aje\/kwi195","volume":"162","author":"Eng SM","year":"2005","journal-title":"Am J Epidemiol"},{"key":"bibr16-EDBK_237423","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1001\/archinte.167.19.2091","volume":"167","author":"Ahn J","year":"2007","journal-title":"Arch Intern Med"},{"key":"bibr17-EDBK_237423","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1207\/s15327914nc4901_2","volume":"49","author":"Radimer KL","year":"2004","journal-title":"Nutr Cancer"},{"key":"bibr18-EDBK_237423","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1002\/ijc.28926","volume":"135","author":"Emaus MJ","year":"2014","journal-title":"Int J Cancer"},{"key":"bibr19-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.10.650"},{"key":"bibr20-EDBK_237423","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1023\/A:1018479020716","volume":"8","author":"van den Brandt PA","year":"1997","journal-title":"Cancer Causes Control"},{"key":"bibr21-EDBK_237423","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1023\/A:1008961931534","volume":"11","author":"Trentham-Dietz A","year":"2000","journal-title":"Cancer Causes Control"},{"key":"bibr22-EDBK_237423","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1002\/ijc.22236","volume":"119","author":"Han D","year":"2006","journal-title":"Int J Cancer"},{"key":"bibr23-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(01)00293-9"},{"key":"bibr24-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9292-y"},{"key":"bibr25-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602763"},{"key":"bibr26-EDBK_237423","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/jamaoncol.2015.3299","volume":"1","author":"Keum N","year":"2015","journal-title":"JAMA Oncol"},{"key":"bibr27-EDBK_237423","doi-asserted-by":"crossref","first-page":"djv088","DOI":"10.1093\/jnci\/djv088","volume":"107","author":"Keum N","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"bibr28-EDBK_237423","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s10549-010-1116-4","volume":"123","author":"Vrieling A","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"bibr29-EDBK_237423","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/cncr.31687","volume":"125","author":"Chlebowski RT","year":"2019","journal-title":"Cancer"},{"key":"bibr30-EDBK_237423","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10552-011-9730-y","volume":"22","author":"Teras LR","year":"2011","journal-title":"Cancer Causes Control"},{"key":"bibr31-EDBK_237423","first-page":"7168734","volume":"2016","author":"Komaroff M","year":"2016","journal-title":"J Obes"},{"key":"bibr32-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv073"},{"key":"bibr33-EDBK_237423","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1158\/1055-9965.EPI-16-0611","volume":"26","author":"Welti LM","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bibr34-EDBK_237423","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.ijo.0800390","volume":"21","author":"French SA","year":"1997","journal-title":"Int J Obes Relat Metab Disord"},{"key":"bibr35-EDBK_237423","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2188\/jea.JE20120102","volume":"23","author":"Suzuki S","year":"2013","journal-title":"J Epidemiol"},{"key":"bibr36-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0495"},{"key":"bibr37-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7607"},{"key":"bibr38-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0789"},{"key":"bibr39-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.414"},{"key":"bibr40-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12783"},{"key":"bibr42-EDBK_237423","first-page":"555616","volume":"3","author":"Shafaee MN","year":"2018","journal-title":"Juniper Online J Public Health"},{"key":"bibr43-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-009-0939-3"},{"key":"bibr44-EDBK_237423","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12885-016-2295-0","volume":"16","author":"Constantinou P","year":"2016","journal-title":"BMC Cancer"},{"key":"bibr45-EDBK_237423","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10549-012-2108-3","volume":"134","author":"Poll\u00e1n M","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"bibr46-EDBK_237423","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/bjsports-2015-094728","volume":"50","author":"Liu L","year":"2016","journal-title":"Br J Sports Med"},{"key":"bibr47-EDBK_237423","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10654-015-0064-z","volume":"31","author":"Bellocco R","year":"2016","journal-title":"Eur J Epidemiol"},{"key":"bibr48-EDBK_237423","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s10552-015-0671-8","volume":"26","author":"Ekenga CC","year":"2015","journal-title":"Cancer Causes Control"},{"key":"bibr49-EDBK_237423","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1158\/1055-9965.EPI-13-0407","volume":"22","author":"Hildebrand JS","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bibr50-EDBK_237423","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/bcr2190","volume":"10","author":"Leitzmann MF","year":"2008","journal-title":"Breast Cancer Res"},{"key":"bibr51-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0582"},{"key":"bibr52-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088759"},{"key":"bibr53-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0756"},{"key":"bibr55-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14854"},{"key":"bibr56-EDBK_237423","volume-title":"Physical Activity Guidelines Advisory Committee Report","author":"Physical Activities Guidelines Advisory Committee","year":"2008"},{"key":"bibr57-EDBK_237423","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1158\/1055-9965.EPI-13-0210","volume":"22","author":"Hastert TA","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bibr58-EDBK_237423","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1158\/1055-9965.EPI-16-0121","volume":"25","author":"Kohler LN","year":"2016","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bibr59-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0990-0"},{"key":"bibr60-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.4.1128"},{"key":"bibr62-EDBK_237423","volume-title":"San Antonio Breast Cancer Symposium","author":"Chlebowski R"},{"key":"bibr63-EDBK_237423","volume-title":"American Society of Clinical Oncology Annual Meeting","author":"Chlebowski R"},{"key":"bibr64-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.3.289"},{"key":"bibr65-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1159\/000322677"},{"key":"bibr66-EDBK_237423","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.SABCS18-GS5-03","volume":"79","author":"Janni W","year":"2019","journal-title":"Cancer Res"},{"key":"bibr67-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1177\/030089161209800101"},{"key":"bibr68-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-017-0040-8"},{"key":"bibr69-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181e0c112"},{"key":"bibr70-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.11.010"},{"key":"bibr71-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.6914"},{"issue":"8","key":"bibr72-EDBK_237423","first-page":"CD007566","author":"Mishra SI","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr73-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030955"},{"key":"bibr74-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.09.012"},{"key":"bibr75-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs207"},{"key":"bibr76-EDBK_237423","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11764-017-0657-5","volume":"12","author":"Brown JC","year":"2018","journal-title":"J Cancer Surviv"},{"key":"bibr77-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21142"},{"key":"bibr78-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0073"},{"key":"bibr79-EDBK_237423","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1007\/s00520-018-4163-8","volume":"26","author":"Fong AJ","year":"2018","journal-title":"Support Care Cancer"},{"key":"bibr80-EDBK_237423","doi-asserted-by":"crossref","first-page":"e12795","DOI":"10.1111\/ecc.12795","volume":"27","author":"Cantwell M","year":"2018","journal-title":"Eur J Cancer Care (Engl)"},{"key":"bibr81-EDBK_237423","first-page":"55","volume":"3","author":"Madsen LT","year":"2012","journal-title":"J Adv Pract Oncol"},{"key":"bibr82-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000596"},{"key":"bibr83-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006853"},{"key":"bibr84-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1207\/s15324796abm2802_5"},{"key":"bibr85-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1037\/a0029886"},{"key":"bibr86-EDBK_237423","volume-title":"Treating Tobacco Use and Dependence: 2008 Update","author":"Tobacco Use and Dependence Guideline Panel","year":"2008"},{"key":"bibr87-EDBK_237423","first-page":"27","volume":"59","author":"Vallis M","year":"2013","journal-title":"Can Fam Physician"},{"key":"bibr88-EDBK_237423","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1249\/MSS.0000000000000664","volume":"47","author":"Riebe D","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"bibr89-EDBK_237423","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12966-018-0680-6","volume":"15","author":"Wong JN","year":"2018","journal-title":"Int J Behav Nutr Phys Act"},{"key":"bibr90-EDBK_237423","doi-asserted-by":"crossref","first-page":"243S","DOI":"10.1093\/jn\/137.1.243S","volume":"137","author":"Stull VB","year":"2007","journal-title":"J Nutr"},{"key":"bibr91-EDBK_237423","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s00520-018-4305-z","volume":"26","author":"Haberlin C","year":"2018","journal-title":"Support Care Cancer"},{"key":"bibr92-EDBK_237423","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jneb.2015.12.006","volume":"48","author":"Vandelanotte C","year":"2016","journal-title":"J Nutr Educ Behav"},{"key":"bibr93-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30456"},{"key":"bibr94-EDBK_237423","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/pon.1465","volume":"18","author":"Pinto BM","year":"2009","journal-title":"Psychooncology"},{"key":"bibr95-EDBK_237423","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1123\/jpah.7.6.784","volume":"7","author":"Hughes D","year":"2010","journal-title":"J Phys Act Health"},{"key":"bibr96-EDBK_237423","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.89"}],"container-title":["American Society of Clinical Oncology Educational Book"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/EDBK_237423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T01:50:35Z","timestamp":1663465835000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/EDBK_237423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":91,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1200\/EDBK_237423"],"URL":"https:\/\/doi.org\/10.1200\/edbk_237423","relation":{},"ISSN":["1548-8748","1548-8756"],"issn-type":[{"value":"1548-8748","type":"print"},{"value":"1548-8756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}