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Similarly, in the metastatic urothelial cancer space, the standard frontline treatment option of platinum-based chemotherapy has changed with the availability of data from EV-302 trial, making the combination of enfortumab vedotin (EV) and pembrolizumab the preferred first-line treatment option. Here, we examine the optimization of treatment intensity and sequencing, focusing on the challenges and opportunities associated with EV\/pembrolizumab therapy, including managing toxicities and exploring alternative dosing approaches. Together, these articles provide a comprehensive overview of contemporary strategies in bladder cancer management, highlighting the importance of individualized treatment approaches, ongoing research, and multidisciplinary collaboration to improve patient outcomes in this complex disease landscape. <\/jats:p>","DOI":"10.1200\/edbk_432054","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T19:59:18Z","timestamp":1716321558000},"source":"Crossref","is-referenced-by-count":18,"title":["Advancements in Urothelial Cancer Care: Optimizing Treatment for Your Patient"],"prefix":"10.1200","volume":"44","author":[{"given":"Gregory","family":"Hemenway","sequence":"first","affiliation":[{"name":"Temple University Health System, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan F.","family":"Anker","sequence":"additional","affiliation":[{"name":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, 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