{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:39:32Z","timestamp":1789825172709,"version":"4.0.1"},"reference-count":123,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am Soc Clin Oncol Educ Book"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Multiple chimeric antigen receptor (CAR) T-cell and bispecific antibody (bsAb) therapies have been approved, demonstrating impressive clinical efficacy in relapsed\/refractory multiple myeloma (MM). Currently, these treatment share overlapping approval indications in the relapsed\/refractory space, highlighting the importance of optimal selection and sequencing to maximize clinical efficacy. For patients previously unexposed to T-cell\u2013directed therapies, several factors should be weighed when both options are available. These factors include access and logistical challenges associated with CAR T-cell therapy, disease-specific factors such as tempo of disease relapse, in addition to patient-specific factors such as frailty, and distinct toxicity profiles across these agents. Sequential therapy, whether it involves CAR T-cell therapy followed by bsAb or vice versa, has demonstrated clinical efficacy. When sequencing these agents, it is crucial to consider various factors that contribute to treatment resistance with careful selection of treatments for subsequent therapy in order to achieve favorable long-term patient outcomes.<\/jats:p>","DOI":"10.1200\/edbk_432204","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T16:00:31Z","timestamp":1718380831000},"source":"Crossref","is-referenced-by-count":25,"title":["Charting the Course: Sequencing Immunotherapy for Multiple Myeloma"],"prefix":"10.1200","volume":"44","author":[{"given":"Meera","family":"Mohan","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Van Oekelen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othman Salim","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"bibr1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024850"},{"key":"bibr2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00933-8"},{"key":"bibr3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"bibr4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204591"},{"key":"bibr5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02528-9"},{"key":"bibr6","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2023000433"},{"key":"bibr7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01504"},{"key":"bibr8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-147983"},{"key":"bibr9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-182130"},{"key":"bibr10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-177968"},{"key":"bibr11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-182388"},{"key":"bibr12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8011"},{"key":"bibr13","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01003-z"},{"key":"bibr14","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02154-5"},{"key":"bibr15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.12.016"},{"key":"bibr16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8036"},{"key":"bibr17","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.283590"},{"key":"bibr18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-181228"},{"key":"bibr19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-159009"},{"key":"bibr20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-159969"},{"key":"bibr21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-157988"},{"key":"bibr22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-177735"},{"key":"bibr23","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(23)01412-X"},{"key":"bibr24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-187409"},{"key":"bibr25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-148723"},{"key":"bibr26","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34756"},{"key":"bibr27","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00963-y"},{"key":"bibr28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-159381"},{"key":"bibr29","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006178"},{"key":"bibr30","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35107"},{"key":"bibr31","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010539"},{"key":"bibr32","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009435"},{"key":"bibr33","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.38961"},{"key":"bibr34","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015956"},{"key":"bibr35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau7746"},{"key":"bibr36","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0734-z"},{"key":"bibr37","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18909"},{"key":"bibr38","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00879-7"},{"key":"bibr39","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00159-6"},{"key":"bibr40","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2018.07.015"},{"key":"bibr41","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8009"},{"key":"bibr42","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01465-x"},{"key":"bibr43","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14213"},{"key":"bibr44","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-22-0074"},{"key":"bibr45","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00629-1"},{"key":"bibr46","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000600"},{"key":"bibr47","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-22-0018"},{"key":"bibr48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213614"},{"key":"bibr49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-178933"},{"key":"bibr50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303379"},{"key":"bibr51","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-174841"},{"key":"bibr52","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26486"},{"key":"bibr53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-173970"},{"key":"bibr54","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-94353-0_4"},{"key":"bibr55","first-page":"372","volume":"16","author":"Shah NN","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"bibr56","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.11.004"},{"key":"bibr57","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0146-z"},{"key":"bibr58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21177-5"},{"key":"bibr59","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01245-5"},{"key":"bibr60","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-137650"},{"key":"bibr61","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02491-5"},{"key":"bibr62","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126397"},{"key":"bibr63","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-178954"},{"key":"bibr64","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010025"},{"key":"bibr65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2308544"},{"key":"bibr66","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-190517"},{"key":"bibr67","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-127309"},{"key":"bibr68","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00842"},{"key":"bibr69","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817226"},{"key":"bibr70","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.247"},{"key":"bibr71","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12254"},{"key":"bibr72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-683847"},{"key":"bibr73","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00207-7"},{"key":"bibr74","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85309"},{"key":"bibr75","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99048"},{"key":"bibr76","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03279"},{"key":"bibr77","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-186395"},{"key":"bibr78","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-187467"},{"key":"bibr79","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-173550"},{"key":"bibr80","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-187755"},{"key":"bibr81","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00462-8"},{"key":"bibr82","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01655-0"},{"key":"bibr83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.10.004"},{"key":"bibr84","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba1786"},{"key":"bibr85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.03.041"},{"key":"bibr86","author":"Van Oekelen O","journal-title":"Cell Rep Med"},{"key":"bibr87","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-611426"},{"key":"bibr88","doi-asserted-by":"publisher","DOI":"10.1038\/nature21349"},{"key":"bibr89","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-023-00402-5"},{"key":"bibr90","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-2188"},{"key":"bibr91","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00413-6"},{"key":"bibr92","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1059715"},{"key":"bibr93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.832645"},{"key":"bibr94","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01365"},{"key":"bibr95","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8012"},{"key":"bibr96","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2023.101628"},{"key":"bibr97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.12.239"},{"key":"bibr98","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000970424.05174.3c"},{"key":"bibr99","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.12052"},{"key":"bibr100","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01023-9"},{"key":"bibr101","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015526"},{"key":"bibr102","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00886-8"},{"key":"bibr103","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-187242"},{"key":"bibr104","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8008"},{"key":"bibr105","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012066"},{"key":"bibr106","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.8013"},{"key":"bibr107","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017848"},{"key":"bibr108","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-166465"},{"key":"bibr109","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-023-00712-0"},{"key":"bibr110","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-187706"},{"key":"bibr111","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01824"},{"key":"bibr112","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00372-6"},{"key":"bibr113","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209900"},{"key":"bibr114","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-190793"},{"key":"bibr115","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.8006"},{"key":"bibr116","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8049"},{"key":"bibr117","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-181304"},{"key":"bibr118","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-184928"},{"key":"bibr119","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-183085"},{"key":"bibr120","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8003"},{"key":"bibr121","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-182330"},{"key":"bibr122","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008936"},{"key":"bibr123","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007923"}],"container-title":["American Society of Clinical Oncology Educational Book"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/EDBK_432204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T16:00:38Z","timestamp":1718380838000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/EDBK_432204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":123,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1200\/EDBK_432204"],"URL":"https:\/\/doi.org\/10.1200\/edbk_432204","relation":{},"ISSN":["1548-8748","1548-8756"],"issn-type":[{"value":"1548-8748","type":"print"},{"value":"1548-8756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"article-number":"e432204"}}