{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:11:36Z","timestamp":1781151096167,"version":"3.54.1"},"reference-count":67,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am Soc Clin Oncol Educ Book"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p> Hematologic malignancies most often present in the sixth or seventh decade of life. Even so, many older adults may be unable to tolerate standard chemotherapy or require supplementary care or dose adjustments to do so. Both in community and academic centers, geriatric assessment (GA) can be used to improve the care of older adults with blood cancers. For example, hematologic oncologists can use GA to guide treatment selection, adjusting for patient frailty and goals, as well as prompt initiation of enhanced supportive care. After initial therapy, GA can improve the identification of older adults with aggressive myeloid malignancies who would benefit from hematopoietic cell transplantation (HCT), inform shared decision making, as well as allow transplanters to tailor conditioning regimen, donor selection, graft-versus-host disease prophylaxis, and pre- and post-HCT treatments. As in HCT, GA can improve the care of older patients with relapsed lymphoma or multiple myeloma eligible for chimeric antigen receptor-T therapy, identifying patients at higher risk for toxicity and providing a baseline for subsequent neurocognitive testing. Here, we review the data supporting GA for the care of older adults with blood cancers, from the community to the academic center. In addition, we explore future directions to optimize outcomes for older adults with hematologic malignancies. <\/jats:p>","DOI":"10.1200\/edbk_432220","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T20:00:30Z","timestamp":1716580830000},"source":"Crossref","is-referenced-by-count":5,"title":["Tailoring Therapy in Older Adults With Hematologic Malignancies"],"prefix":"10.1200","volume":"44","author":[{"given":"Brendan L.","family":"Mangan","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark","family":"DuMontier","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"},{"name":"Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith O.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Novant Health Cancer Institute\/SCOR NCORP, Winston-Salem, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Abel","sequence":"additional","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon R.","family":"McCurdy","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology\/Department of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"bibr1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31694-5"},{"key":"bibr2","volume-title":"Surveillance, Epidemiology, and End Results (SEER) Program Populations (1969-2020)","year":"2022"},{"key":"bibr3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21638"},{"key":"bibr4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1988.tb02362.x"},{"key":"bibr5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00933"},{"key":"bibr6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2021.11.002"},{"key":"bibr7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2022.02.005"},{"key":"bibr8","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00263"},{"key":"bibr9","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.245803"},{"key":"bibr10","doi-asserted-by":"publisher","DOI":"10.1200\/OP.22.00842"},{"key":"bibr11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00930"},{"key":"bibr12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01789-X"},{"key":"bibr13","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000096"},{"key":"bibr14","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00425-3"},{"key":"bibr15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00899"},{"key":"bibr16","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-021-00294-9"},{"key":"bibr17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.04.003"},{"key":"bibr18","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013671"},{"key":"bibr19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02465"},{"key":"bibr20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021015200"},{"key":"bibr21","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17384"},{"key":"bibr22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-615187"},{"key":"bibr23","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.4158"},{"key":"bibr24","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.56106"},{"key":"bibr25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-746420"},{"key":"bibr26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02809"},{"key":"bibr27","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.278802"},{"key":"bibr28","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010003"},{"key":"bibr29","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000790"},{"key":"bibr30","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-772368"},{"key":"bibr31","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-01092-2"},{"key":"bibr32","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03380"},{"key":"bibr33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00165"},{"key":"bibr34","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00118"},{"key":"bibr35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01007"},{"key":"bibr36","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00779-2"},{"key":"bibr37","doi-asserted-by":"publisher","DOI":"10.1200\/OP.21.00743"},{"key":"bibr38","unstructured":"Jensen-Battaglia M, Sohn M, Consagra W, et al: Trajectories of physical well-being among adults with acute myeloid leukemia. 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