{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:53:09Z","timestamp":1787637189643,"version":"build-2736575974"},"reference-count":57,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am Soc Clin Oncol Educ Book"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Hodgkin lymphoma (HL) is a treatable cancer with an incidence peak in adolescent and young adult years. Treatment strategies have been developed to balance the intensity of therapy needed to maintain disease-free survival while simultaneously preserving overall survival. Risk-based, response-adapted frontline therapy has long used a combination of chemotherapy and radiotherapy (RT). Successive clinical trials over the past three decades have safely reduced cumulative alkylator, anthracycline, and RT exposures for many patients. The advent of checkpoint inhibitors and the CD30-targeted antibody drug conjugate, brentuximab vedotin, has provided new options for de-escalation of conventional therapies associated with late effects in survivors treated at a young age. The ability to evaluate novel agents has been accelerated in collaborative trials inclusive of children and adolescents within the US National Clinical Trials Network and between the Children's Oncology Group and the EuroNet Pediatric Hodgkin Lymphoma Consortium. With numerous treatment options, patients with HL and their clinicians have an opportunity for shared decision making from diagnosis, through cancer treatment, and into survivorship. Given excellent survival outcomes, decisions about treatment in classic HL should be collaborative and attention to long-term survivorship needs should remain a high priority. Patient-reported outcomes remain an important tool to aid clinicians working with survivors to optimize health status and related quality of life for decades after HL therapy.<\/jats:p>","DOI":"10.1200\/edbk_432420","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T15:59:30Z","timestamp":1716566370000},"source":"Crossref","is-referenced-by-count":24,"title":["Pediatric and Adolescent Hodgkin Lymphoma: Paving the Way for Standards of Care and Shared Decision Making"],"prefix":"10.1200","volume":"44","author":[{"given":"Justine M.","family":"Kahn","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Columbia University Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mauz-Korholz","sequence":"additional","affiliation":[{"name":"Justus-Liebig University of Giessen, Giessen, and Medical Faculty of the Martin-Luther-University of Halle-Wittenberg, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Education & Services, The Leukemia & Lymphoma Society, Rye Brook, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Milgrom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"bibr1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278796"},{"key":"bibr2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01186"},{"key":"bibr3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7042"},{"key":"bibr4","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16197"},{"key":"bibr5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.4853"},{"key":"bibr6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26421"},{"key":"bibr7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.07.1716"},{"key":"bibr8","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7064"},{"key":"bibr9","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31519"},{"key":"bibr10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.5410"},{"key":"bibr11","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16014"},{"key":"bibr12","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00470-8"},{"key":"bibr13","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00019-0"},{"key":"bibr15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx005"},{"key":"bibr16","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.2012659"},{"key":"bibr17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01799"},{"key":"bibr18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206660"},{"key":"bibr19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03286"},{"key":"bibr20","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30580"},{"key":"bibr21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-180107"},{"key":"bibr22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-186719"},{"key":"bibr23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-189652"},{"key":"bibr24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-187028"},{"key":"bibr25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02423"},{"key":"bibr26","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.51062"},{"key":"bibr27","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-023-01401-9"},{"key":"bibr28","doi-asserted-by":"publisher","DOI":"10.1200\/OP.21.00275"},{"key":"bibr29","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00349-5"},{"key":"bibr30","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28562"},{"key":"bibr31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408648"},{"key":"bibr32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206125"},{"key":"bibr33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.362"},{"key":"bibr34","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022912"},{"key":"bibr35","volume-title":"Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents"},{"key":"bibr36","doi-asserted-by":"crossref","unstructured":"SWOG S1826, a randomized study of nivolumab(N)-AVD versus brentuximab vedotin(BV)-AVD in advanced stage (AS) classic Hodgkin lymphoma (HL). 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