{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:12:12Z","timestamp":1782195132664,"version":"3.54.5"},"reference-count":36,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>To evaluate the toxicity profile and efficacy of postoperative ultra-hypofractionated radiation therapy in elderly patients with breast cancer.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>This is a nonrandomized, single-center, prospective Phase II trial. Patients with breast cancer older than 65 years were treated with ultra-hypofractionated radiation therapy in 5 fractions of 5.7 Gy on alternate days in the breast or chest wall, or regional lymph nodes. The primary end point was acute toxicity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              A total of 60 patients were analyzed, with a median follow-up of 42.5 months (range, 13.8-66.2). Most patients presented pathologic stage I (56.6%, n = 34) or stage II (33.3%, n = 20) disease. Regional lymph node irradiation was performed in 22% (n = 13) of patients. During treatment, 51% (n = 31) of patients experienced grade 1 or 2 acute toxicity, with no cases of grade 3 acute toxicity reported. Late toxicity included 1.7% (n = 1) of patients developing grade 3 fibrosis and 1.7% (n = 1) developing grade 3 pneumonitis. Regional lymph node irradiation was not associated with a statistically significant increase in toxicity risk (\n              <jats:italic>P<\/jats:italic>\n              = .194). Cosmesis evaluations revealed no significant changes when comparing pretreatment assessments with evaluations at 10 weeks (\n              <jats:italic>P<\/jats:italic>\n              = .223) and 26 weeks (\n              <jats:italic>P<\/jats:italic>\n              = .615) post-treatment. Quality of life was not adversely affected, regardless of whether regional lymph nodes were irradiated. Recurrence rates included two patients with both locoregional and distant recurrence and five patients with distant recurrence. The 3-year disease-free survival probability was 81.7%, and the 3-year overall survival probability was 86.7%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>This study demonstrates the safety of ultra-hypofractionated radiation therapy in terms of toxicity in patients with breast cancer. The findings for side effects, cosmesis, quality of life, and survival outcomes are consistent with those observed in moderately hypofractionated radiation therapy regimens, suggesting its use as a viable treatment option in this demographic.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-24-00277","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T20:59:16Z","timestamp":1741381156000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Phase II Evaluation of Ultra-Hypofractionated Postoperative Radiation Therapy for Breast Cancer: Toxicity and Efficacy in a Single-Center Nonrandomized Prospective Study"],"prefix":"10.1200","clinical-trial-number":[{"clinical-trial-number":"nct05850637","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-6913","authenticated-orcid":true,"given":"Marcel","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Radiology and Oncology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"},{"name":"Instituto de Pesquisa Prevent Senior, Sao Paulo, Brazil"},{"name":"Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-4320","authenticated-orcid":true,"given":"Vinicius de Carvalho","family":"Gico","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Prevent Senior, Sao Paulo, Brazil"},{"name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Casimiro","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia da Sa\u00fade da Mulher, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0929-8885","authenticated-orcid":true,"given":"Bruno","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Santos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-5504","authenticated-orcid":true,"given":"Elson","family":"Santos Neto","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, AC Camargo Cancer Center- Sao Paulo, Brazil"},{"name":"Department of Radiation Oncology, HCor Associa\u00e7\u00e3o Beneficente S\u00edria, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana Veronica","family":"Mendoza Lopez","sequence":"additional","affiliation":[{"name":"Centro de Estudos e Tecnologias Convergentes para Oncologia de Precis\u00e3o (Comprehensive Center for Precision Oncology), Centro de Investiga\u00e7\u00e3o Translacional em Oncologia, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Vilela","family":"Costa Pinto","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Prevent Senior, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-3684","authenticated-orcid":true,"given":"Gustavo Nader","family":"Marta","sequence":"additional","affiliation":[{"name":"Department of Radiology and Oncology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"},{"name":"Department of Radiation Therapy, Hospital S\u00edrio Liban\u00eas, Sao Paulo, Brazil"},{"name":"Latin American Cooperative Oncology Group (LACOG), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61629-2"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60488-8"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022152"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020989"},{"key":"e_1_3_6_6_2","first-page":"1255","volume-title":"Perez & Brady\u2019s Principles and Practice of Radiation Oncology","author":"Halperin EC","year":"2018","unstructured":"Halperin EC, Wazer DE, Perez CA, et al: Perez & Brady\u2019s Principles and Practice of Radiation Oncology (ed 6), 2018, pp 1255-1395","edition":"6"},{"key":"e_1_3_6_7_2","first-page":"CD003860","article-title":"Hypofractionated radiation therapy for early breast cancer","volume":"2016","author":"Hickey BE","year":"2016","unstructured":"Hickey BE, James ML, Lehman M, et al: Hypofractionated radiation therapy for early breast cancer. 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