{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:12Z","timestamp":1753883532160,"version":"3.41.2"},"reference-count":61,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>The global burden of lymphoma is substantial because of the increase in its incidence in recent decades. However, disease characteristics vary across different geographical locations. Numerous immunohistochemistry markers and molecular studies are essential to determine lymphoma diagnosis and prognosis. This poses significant challenges in developing countries with limited health care resources. This large-scale study assesses the frequency of non-Hodgkin lymphoma (NHL) in Indonesia over the past 15 years, analyses its clinicopathologic features, and predicts future trends.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>This retrospective study collected lymphoma patients diagnosed at the Department of Anatomical Pathology Dr. Cipto Mangunkusumo National Central General Hospital, Indonesia, from 2009 until 2023. All lymphoma diagnoses were confirmed by using ancillary tools classified as an enhanced lymphoma panel according to a resource-stratified guideline. We analyzed the clinicopathologic features of each NHL type and further applied the Autoregressive Integrated Moving Average model to predict future incidence trends.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>The study consisted of 7,368 NHL patients. Among these, B-cell lymphomas accounted for 90.6%, with diffuse large B-cell lymphoma being the most prevalent subtype (68.8%), followed by follicular lymphoma (8.8%) and marginal zone lymphoma (5.8%). Extranodal natural killer\/T-cell lymphoma, nasal type, is the most common T-cell lymphoma found (26.3%). All types of lymphoma were found to be more common in males (57.7%). Extranodal involvement, particularly in the tonsil and upper respiratory tract, was frequently observed. Projection analysis indicates a steady increase in lymphoma patients in the future.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>This study highlights the distribution and burden of NHL in Indonesia over 15 years. The overall epidemiologic pattern of NHL in this study aligns with the results observed in other Asian countries. The rising incidence of lymphoma requires improved health care infrastructure and prevention strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-24-00346","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T20:59:27Z","timestamp":1731013167000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8920-7873","authenticated-orcid":true,"given":"Agnes Stephanie","family":"Harahap","sequence":"first","affiliation":[{"name":"Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia\/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia"},{"name":"Human Cancer Research Center-Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7915-5536","authenticated-orcid":true,"given":"Maria Francisca","family":"Ham","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia\/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia"},{"name":"Human Cancer Research Center-Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-9029","authenticated-orcid":true,"given":"Andree","family":"Kurniawan","sequence":"additional","affiliation":[{"name":"Subspecialist Program Study, Hematology and Medical Oncology, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia\/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5853-8041","authenticated-orcid":true,"given":"Stefanny","family":"Charles","sequence":"additional","affiliation":[{"name":"Human Cancer Research Center-Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-1943","authenticated-orcid":true,"given":"Felix","family":"Wijovi","sequence":"additional","affiliation":[{"name":"Human Cancer Research Center-Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-7735","authenticated-orcid":true,"given":"Lugyanti","family":"Sukrisman","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia\/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1059914"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.738693"},{"key":"e_1_3_4_4_2","volume-title":"Global Cancer Observatory Cancer Today","author":"Ferlay J","year":"2024","unstructured":"Ferlay J, Ervik M, Lam F, et al: Global Cancer Observatory Cancer Today. Lyon, France, Presented at the International Agency for Research on Cancer, 2024"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyz202"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70450-9"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2392"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.5772\/31746"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph8030607"},{"key":"e_1_3_4_11_2","unstructured":"Akkari Y Alaggio R Campbell P et al: Haematolymphoid tumours. Presented at the International Agency for Research on Cancer Lyon France June 19 2024"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01281-9"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-158830"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21824"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2017.05.005"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-77"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.31557\/apjec.2021.4.1.33-38"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10132-2"},{"key":"e_1_3_4_19_2","first-page":"25620","article-title":"Clinicopathological spectrum of Hodgkin\u2019s and non-Hodgkin\u2019s lymphoma: A tertiary care cancer hospital study in Pakistan","volume":"14","author":"Aslam W","year":"2022","unstructured":"Aslam W, Habib M, Aziz S: Clinicopathological spectrum of Hodgkin\u2019s and non-Hodgkin\u2019s lymphoma: A tertiary care cancer hospital study in Pakistan. Cureus 14:25620, 2022","journal-title":"Cureus"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2590-5"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3329\/bmj.v41i1.18779"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-440073"},{"key":"e_1_3_4_23_2","unstructured":"Naresh KN Ferry JA Qing DM et al: B-cell lymphoproliferative disorders and neoplasms. Presented at the International Agency for Research on Cancer Lyon France June 19 2024"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.03.017"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2016-LB-012"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1436"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-169045"},{"key":"e_1_3_4_28_2","unstructured":"Rosenwald A Delabie J Medeiros LJ et al: Diffuse large B-cell lymphoma NOS. Presented at the International Agency for Research on Cancer Lyon France June 19 2024"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-461848"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13085"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2020.02.001"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357"},{"key":"e_1_3_4_33_2","unstructured":"Xerri L Medeiros LJ Klapper W et al: Follicular lymphoma. Presented at the International Agency for Research on Cancer Lyon France June 19 2024"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-191161"},{"key":"e_1_3_4_36_2","first-page":"100126","article-title":"Comprehensive analysis of peripheral T-cell and natural killer\/T-cell lymphoma in Asian patients: A multinational, multicenter, prospective registry study in Asia","volume":"10","author":"Yoon SE","year":"2021","unstructured":"Yoon SE, Song Y, Kim SJ, et al: Comprehensive analysis of peripheral T-cell and natural killer\/T-cell lymphoma in Asian patients: A multinational, multicenter, prospective registry study in Asia. Lancet Reg Health West Pac 10:100126, 2021","journal-title":"Lancet Reg Health West Pac"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134270"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.213512"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2018.103"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26744"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-517292"},{"key":"e_1_3_4_42_2","first-page":"3055","article-title":"Pathological and clinical characteristics of 1,248 non-Hodgkin\u2019s lymphomas from a regional cancer hospital in Shandong, China","volume":"12","author":"Liu J","year":"2011","unstructured":"Liu J, Song B, Fan T, et al: Pathological and clinical characteristics of 1,248 non-Hodgkin\u2019s lymphomas from a regional cancer hospital in Shandong, China. Asian Pac J Cancer Prev 12:3055-3061, 2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23187"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24934"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17874"},{"key":"e_1_3_4_46_2","unstructured":"Sayed S Leoncini L Siebert R et al: Burkitt lymphoma. Presented at the International Agency for Research on Cancer Lyon France June 19 2024"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5149(03)00039-X"},{"key":"e_1_3_4_48_2","first-page":"42","article-title":"Extranodal involvement in lymphoma - a pictorial essay and retrospective analysis of 281 PET\/CT studies","volume":"2","author":"Das J","year":"2014","unstructured":"Das J, Ray S, Sen S, et al: Extranodal involvement in lymphoma - a pictorial essay and retrospective analysis of 281 PET\/CT studies. Asia Ocean J Nucl Med Biol 2:42-56, 2014","journal-title":"Asia Ocean J Nucl Med Biol"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2007.05.009"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.301095088"},{"key":"e_1_3_4_51_2","unstructured":"Cheuk W Delabie J Ott G et al: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Presented at the International Agency for Research on Cancer Lyon France June 19 2024"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000987"},{"key":"e_1_3_4_53_2","first-page":"100971","article-title":"Cancer disparities in Southeast Asia: Intersectionality and a call to action","volume":"41","author":"Feliciano EJG","year":"2023","unstructured":"Feliciano EJG, Ho FDV, Yee K, et al: Cancer disparities in Southeast Asia: Intersectionality and a call to action. Lancet Reg Health West Pac 41:100971, 2023","journal-title":"Lancet Reg Health West Pac"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-08527-9"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2021.7304"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026164"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16489"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041417"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-07956-w"},{"key":"e_1_3_4_60_2","first-page":"129","article-title":"Non-Hodgkin\u2019s lymphoma in Jakarta","volume":"5","author":"Reksodiputro AH","year":"2011","unstructured":"Reksodiputro AH, Irawan C, Hardjolukito E, et al: Non-Hodgkin\u2019s lymphoma in Jakarta. Indonesian J Cancer 5:129-133, 2011","journal-title":"Indonesian J Cancer"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9864.1000257"},{"key":"e_1_3_4_62_2","first-page":"129","article-title":"Incorporation of brentuximab vedotin in the treatment of lymphoma: Current evidence and potential use in Indonesia","volume":"5","author":"Purwanto I","year":"2020","unstructured":"Purwanto I: Incorporation of brentuximab vedotin in the treatment of lymphoma: Current evidence and potential use in Indonesia. Acta Interna J Inter Med 5:129-133, 2020","journal-title":"Acta Interna J Inter Med"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/GO-24-00346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T20:59:32Z","timestamp":1731013172000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/GO-24-00346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1200\/GO-24-00346"],"URL":"https:\/\/doi.org\/10.1200\/go-24-00346","relation":{},"ISSN":["2687-8941"],"issn-type":[{"type":"electronic","value":"2687-8941"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2400346"}}