{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:51:31Z","timestamp":1753883491787,"version":"3.41.2"},"reference-count":37,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>This study aimed to report the neurological manifestations of patients with CNS metastases (CNSm) and to determine their association with survival in patients with brain metastases (BrMs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>A retrospective analysis of patients with CNSms (BrMs or neoplastic meningitis) seen at two referral centers between 2010 and 2022. The neurological manifestations and their association with survival were measured and presented.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Among 822 patients with CNSms, the most common neurological manifestations were headache, focal weakness, visual disorders, nausea\/vomiting, seizures, and altered mental status (53%, 35%, 24%, 23%, 22%, and 18%, respectively). In patients with BrMs, neurological manifestations associated with survival were asymptomatic (hazard ratio [HR], 0.48 [95% CI, 0.31 to 0.73];\n              <jats:italic>P<\/jats:italic>\n              = .001), focal weakness (HR, 1.26 [95% CI, 1.02 to 1.54];\n              <jats:italic>P<\/jats:italic>\n              = .027), or visual disorders (HR, 1.26 [95% CI, 1.01 to 1.58];\n              <jats:italic>P<\/jats:italic>\n              = .045).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Neurological manifestations in patients with BrMs are associated with survival and can aid in prognostic stratification.<\/jats:p>\n          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