{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:00Z","timestamp":1753883520100,"version":"3.41.2"},"reference-count":45,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy is used commonly for pediatric Hodgkin lymphoma (pHL) in low- and middle-income countries. The role of radiotherapy (RT) after ABVD in pHL is uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>We conducted a systematic review to explore the use of ABVD with or without RT in pHL. Key clinical questions included the number of cycles of ABVD, indications for and dose of RT, and outcomes by risk group. A search was performed in PubMed. Articles reporting survival outcomes by risk group were included.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Of 97 articles identified in the literature search, nine met inclusion criteria. Chemotherapy consisted of four to six cycles in limited disease and mostly six cycles in advanced disease. Three studies used RT for all patients within a specified risk group. Six studies dictated an adapted RT approach, with 3%-43% of the patients receiving RT for bulky adenopathy, slow early response (SER), and\/or incomplete response. Radiation doses ranged between 20 and 36 Gy. The progression-free survival and overall survival at 4-10 years ranged from 84% to 100% and 93%-100% in limited disease and 50%-84.4% and 75%-95.3% in advanced disease, respectively. Studies did not directly assess the impact of certain chemotherapy or RT strategies. Recommendations were made after reviewing outcomes with particular approaches.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Four cycles of ABVD are recommended for limited disease, and six cycles of ABVD are recommended for advanced disease. In both limited and advanced diseases, RT is recommended with a dose of 20-21 Gy only to sites of bulky and\/or SER, with a boost of up to 36 Gy to sites of incomplete response. This approach could spare radiation for at least half of the patients with limited disease and one third of advanced disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-24-00485","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T19:59:38Z","timestamp":1750967978000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Curative Treatment of Pediatric Hodgkin Lymphoma With Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine and Consolidation Radiotherapy: A Systematic Review and Suggested Recommendations"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-3890","authenticated-orcid":true,"given":"Josu\u00e9","family":"Hern\u00e1ndez-Ben\u00edtez","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitario Dr Jos\u00e9 Eleuterio Gonz\u00e1lez, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7063-6332","authenticated-orcid":true,"given":"Alejandra","family":"L\u00f3pez-Azcarraga","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Infatil de M\u00e9xico Federico G\u00f3mez, Ciduad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-9355","authenticated-orcid":true,"given":"Jamie E.","family":"Flerlage","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-2002","authenticated-orcid":true,"given":"Sharon","family":"Castellino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory School of Medicine, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-1532","authenticated-orcid":true,"given":"Paula","family":"Aristizabal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of California San Diego, La Jolla, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford S.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic Jacksonville, Jacksonville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-6967","authenticated-orcid":true,"given":"Sarah A.","family":"Milgrom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Jos\u00e9 Aguiar","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hospital de Amor Infantojuvenil de Barretos, Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-034X","authenticated-orcid":true,"given":"Raymond B.","family":"Mailhot Vega","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28562"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.07.1716"},{"key":"e_1_3_7_4_2","unstructured":"National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in Oncology: Pediatric Hodgkin Lymphoma. 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