{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:51:44Z","timestamp":1753883504157,"version":"3.41.2"},"reference-count":12,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Clinical and histopathologic diagnosis of pediatric mature B-cell lymphomas (eg, Burkitt lymphoma [BL]) must be accurate to select appropriate risk-based treatment. The Central American Pediatric Hematology-Oncology Association (AHOPCA) in 2000 implemented standardized, resource-adapted treatments for these lymphomas. We evaluated the concordance of local histopathologic diagnoses through central review, determined the impact on therapy selection, and described the clinical characteristics and outcomes of pediatric patients with these lymphomas. We suggest recommendations to improve the accuracy of diagnoses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>Pathology samples and reports were submitted by six AHOPCA sites to St Jude Children's Research Hospital for central review. The concordance of sample assessments was evaluated using three criteria: histologic diagnosis, morphology, and immunohistochemistry. Clinical characteristics, treatment, and outcomes were also analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Of the 68 eligible patients, 53 (78%) received an accurate pathologic diagnosis of BL. For nine (13%) patients, diagnoses changes with therapy implications were made upon central review, while in six patients, there was a minor disagreement with no therapy implications. Most (87%) patients presented with advanced disease. Detailed cellular features were absent in many reports, and immunohistochemistry was routinely performed at only one site. Of the 50 patients whose treatment data were reported, 44 (88%) completed therapy, five died during treatment, and one abandoned treatment. Treatment outcome was satisfactory: 3-year event-free survival was 74% (SE \u00b1 11%), and overall survival was 73% (SE \u00b1 11%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Pathology laboratories in limited-resource hospitals and regions need further optimization to increase accurate diagnoses of mature B-cell lymphomas. Creating regional pathology networks will enhance diagnostic support. Despite resource limitations and advanced disease at presentation, the AHOPCA sites' adapted treatment strategies have improved patient outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-24-00491","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T20:59:16Z","timestamp":1741381156000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium"],"prefix":"10.1200","author":[{"given":"Priya","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pathology, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-4611","authenticated-orcid":true,"given":"Monika L.","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"},{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN"},{"name":"M\u00e9dicins Sans Fronti\u00e9res, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-0180","authenticated-orcid":true,"given":"John K.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Jude Children's Research Hospital, Memphis, TN"},{"name":"Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godwin","family":"Job","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-3619","authenticated-orcid":true,"given":"Teresa C.","family":"Santiago","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Service, Hospital Escuela Universitario, Tegucigalpa, Honduras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-9605","authenticated-orcid":true,"given":"Miguela A.","family":"Caniza","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"},{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-8181","authenticated-orcid":true,"given":"Asya","family":"Agulnik","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"},{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale Y.","family":"Gassant","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hospital Saint Damien, Port-au-Prince, Haiti"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-3559","authenticated-orcid":true,"given":"Wendy C.","family":"G\u00f3mez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hospital Infantil Dr Robert Reid Cabral, Santo Domingo, Rep\u00fablica Dominicana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia J.","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology\/Oncology, Hospital Infantil Manuel de Jesus Rivera La Mascota, Managua, Nicaragua"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Garrido","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Unidad de Oncologia Pedi\u00e1trica, Francisco Marroquin University, School of Medicine, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6883-2606","authenticated-orcid":true,"given":"Roy","family":"Rosado","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Unidad de Oncologia Pedi\u00e1trica, Francisco Marroquin University, School of Medicine, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soad","family":"Fuentes Alab\u00ed","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hospital de Ni\u00f1os Benjamin Bloom, San Salvador, El Salvador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-4929","authenticated-orcid":true,"given":"Valentino","family":"Conter","sequence":"additional","affiliation":[{"name":"Pediatric Hemato-Oncology, Fondazione Tettamanti, IRCCS San Gerardo, Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-3478","authenticated-orcid":true,"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela K.","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-3113","authenticated-orcid":true,"given":"Paola","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"},{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2360-8946","authenticated-orcid":true,"given":"Carlos","family":"Rodriguez 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