{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:25:07Z","timestamp":1787729107387,"version":"build-2784847793"},"reference-count":57,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>\n              Lineage-specific cellular plasticity is one of the emerging hallmarks of cancer. The undifferentiated state of anaplastic thyroid cancer (ATC) represents an instance of cellular plasticity where lineage-specific molecular markers are underacknowledged. In this study, we identified recurrent mutations in the thyroid hormone receptor \u03b1 (\n              <jats:italic toggle=\"yes\">THRA<\/jats:italic>\n              ) gene, which may play a role in lineage-specific cellular plasticity in ATC.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>We performed whole-exome sequencing and targeted sequencing of 68 formalin-fixed paraffin-embedded orphan tumors of ATC from Indian patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Our analysis reveals the hallmark mutations in\n              <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n              (approximately 42%),\n              <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n              (approximately 10.3%),\n              <jats:italic toggle=\"yes\">KRAS<\/jats:italic>\n              (approximately 2.9%),\n              <jats:italic toggle=\"yes\">NRAS<\/jats:italic>\n              (29.4%),\n              <jats:italic toggle=\"yes\">HRAS<\/jats:italic>\n              (23.5%),\n              <jats:italic toggle=\"yes\">NF1<\/jats:italic>\n              (1.5%),\n              <jats:italic toggle=\"yes\">AKT1<\/jats:italic>\n              (approximately 2.9%), and\n              <jats:italic toggle=\"yes\">PIK3CA<\/jats:italic>\n              (approximately 1.5%) genes. Interestingly, we found significant mutations in\n              <jats:italic toggle=\"yes\">THRA<\/jats:italic>\n              (approximately 11%) in our cohort, unlike the White population, which is a substantial gene in the thyroid cell's differentiation process.\n              <jats:italic toggle=\"yes\">THRA<\/jats:italic>\n              mutations co-occur with TP53 and other hallmark genes, which suggests a synergetic molecular mechanism in phenotypic change in ATC.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>\n              Our data reveal the significant association of\n              <jats:italic toggle=\"yes\">THRA<\/jats:italic>\n              mutations potentially influencing cellular plasticity in a subset of patients with ATC.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-24-00610","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T19:59:11Z","timestamp":1752782351000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive Genomic Profiling of Anaplastic Thyroid Cancer Identifies Alterations in\n            <i>THRA<\/i>\n            , a Potential Modifier of Cellular Plasticity"],"prefix":"10.1200","author":[{"given":"Vaishakhi","family":"Trivedi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India"},{"name":"Homi Bhabha National Institute, Training School Complex, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-2744","authenticated-orcid":true,"given":"Vanita","family":"Noronha","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Tata Memorial Hospital, Mumbai, 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