{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:01:21Z","timestamp":1791666081121,"version":"4.3.4"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Prostate cancer poses a significant public health challenge in the Middle East, with advanced-stage diagnoses and high mortality rates. However, projections regarding its future incidence are limited. The aims of this study were to estimate prostate cancer incidence in the region through 2050, to evaluate socioeconomic factors contributing to regional disparities, and to provide insights to inform future health care policies and resource allocation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>\n              Data from the Global Cancer Observatory were analyzed for Middle Eastern countries, with Europe and North America included for comparison. The percentage change in incidence between 2022 and 2050 was compared across regions using the Mann-Whitney\n              <jats:italic toggle=\"yes\">U<\/jats:italic>\n              test. Additional subgroup analyses based on income level and Human Development Index were performed using Kruskal-Wallis test. Spearman rank correlation was used to explore the association between incidence trends and socioeconomic indicators.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              In 2022, Middle Eastern countries reported 50,944 patients with newly diagnosed prostate cancer, accounting for 3.47% of global incidence. The projected increase in prostate cancer incidence by 2050 was significantly higher in the Middle East compared with Europe and North America (mean rank, 12.50\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              1.50;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .009). Higher income countries exhibited a greater percentage increase (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .033), and the income level correlated positively with incidence trends (\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              = 59.6%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .006). Countries with increasing incidence rates had a markedly higher percentage change than those expected to decline (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .031).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Prostate cancer incidence in the Middle East is expected to rise substantially by 2050, with socioeconomic disparities influencing disease trends. These findings highlight the urgent need for targeted awareness campaigns, improved screening strategies, enhanced oncology infrastructure, and strengthened cancer registries to mitigate the projected burden and improve outcomes in the region.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-25-00098","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T19:59:37Z","timestamp":1748548777000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Projected Prostate Cancer Incidence in the Middle East by 2050: Socioeconomic Disparities and Future Implications"],"prefix":"10.1200","author":[{"given":"James","family":"Parisi","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-3233","authenticated-orcid":true,"given":"Yetkin","family":"Tuac","sequence":"additional","affiliation":[{"name":"Department of Statistics, Ankara University, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Argun","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2801-8413","authenticated-orcid":true,"given":"Garrett","family":"Kearney","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3680-3932","authenticated-orcid":true,"given":"Luke W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-5521","authenticated-orcid":true,"given":"Ozlem","family":"Aynaci","sequence":"additional","affiliation":[{"name":"Karadeniz Technical University, Trabzon, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-4357","authenticated-orcid":true,"given":"Nadeem","family":"Pervez","sequence":"additional","affiliation":[{"name":"UAE University, Al Ain, Abu Dhabi, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-7270","authenticated-orcid":true,"given":"Layth","family":"Mula-Hussain","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dalhousie University, Halifax, Canada"},{"name":"College of Medicine, Ninevah University, Mosul, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-0762","authenticated-orcid":true,"given":"Jonathan E.","family":"Leeman","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-6317","authenticated-orcid":true,"given":"Miranda B.","family":"Lam","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0101-0951","authenticated-orcid":true,"given":"Mutlay","family":"Sayan","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.811044"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2018.5.21986"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/2090598X.2021.2024984"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.961086"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1172864"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-024-01427-6"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6689"},{"key":"e_1_3_5_9_2","article-title":"Prostate cancer awareness in the Middle East: A cross-sectional international study","author":"Sayan M","unstructured":"Sayan M, Eren AA, Tuac Y, et al: Prostate cancer awareness in the Middle East: A cross-sectional international study. 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