{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:15:01Z","timestamp":1785014101829,"version":"3.55.0"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>We assessed radiotherapy (RT) utilization and completion among pediatric patients with brain tumor treated at Children's Cancer Hospital Egypt (CCHE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted among pediatric patients with brain tumor treated at CCHE between 2009 and 2020. Patients were categorized on the basis of demographics, tumor types, RT utilization status (prescribed, not prescribed, and did not complete), and geographic place of residence (urban\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      rural). RT utilization was stratified by tumor type and geographic region and compared using chi-square tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 3,977 pediatric patients with brain tumor, 2,327 (58.5%) were prescribed RT. The highest RT utilization was observed among patients with diffuse intrinsic pontine glioma (DIPG; 98.2%) and germinoma (98.0%), while nonoptic low-grade glioma (LGG; 11.2%) and optic pathway glioma (OPG; 2.0%) had the lowest among patients prescribed RT, 2,264 (97.2%) completed treatment. The highest noncompletion was observed in patients with atypical teratoid rhabdoid tumor (ATRT; 6.7%) and nonoptic LGG (9.7%). Urban patients had a higher rate of RT completion (98.3%) compared with rural patients (95.9%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>RT utilization and completion varied significantly by tumor type, reflecting evidence-based treatment protocols and tumor-specific challenges. Geographic disparities in RT completion underscore systemic health care inequities in Egypt. These findings emphasize the need for targeted interventions, including decentralized radiotherapy delivery models and public health strategies, to improve access to and adherence to radiotherapy among underserved populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-25-00111","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T20:58:13Z","timestamp":1766177893000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Radiotherapy Utilization and Treatment Continuity of Pediatric Patients With Brain Tumor in Egypt: A Decade of Data"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4182-0876","authenticated-orcid":true,"given":"Breana","family":"Wayne","sequence":"first","affiliation":[{"name":"Department of Public Health, Washington University in St Louis Brown School of Public Health, St Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-6528","authenticated-orcid":true,"given":"Mohamed Saad","family":"Zaghloul","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, National Cancer Institute, Cairo University &amp; Children's Cancer Hospital, Egypt 57357, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3856-4015","authenticated-orcid":true,"given":"Mohamed","family":"El-Beltagy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elhemaly","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department, National Cancer Institute, Cairo University &amp; Children's Cancer Hospital 57357, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Refaat","sequence":"additional","affiliation":[{"name":"Radiology Department, National Cancer Institute, Cairo University &amp; Children's Cancer Hospital 57357, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Taha","sequence":"additional","affiliation":[{"name":"Pathology Department, National Cancer Institute, Cairo University &amp; Children's Cancer Hospital 57357, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Sameh","sequence":"additional","affiliation":[{"name":"Research Department, Children's Cancer Hospital, Egypt 57357, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-8972","authenticated-orcid":true,"given":"Chloe","family":"Teasdale","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, The City University of New York (CUNY) School of Public Health New York, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-360X","authenticated-orcid":true,"given":"Amr S.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Community Health and Social Medicine, The City University of New York (CUNY) School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2021.101942"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.10.047"},{"key":"e_1_3_5_4_2","first-page":"1","article-title":"Pediatric oncology, palliative care and low- or middle-income countries: A call for action","volume":"10","author":"Siddiqui MF","year":"2023","unstructured":"Siddiqui MF, Nohra L, Saleh M, et al: Pediatric oncology, palliative care and low- or middle-income countries: A call for action. 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Rosenblatt E Zubizaretta E (eds): Vienna Austria International Atomic Energy Agency 2017. https:\/\/www-pub.iaea.org\/MTCD\/Publications\/PDF\/P1638_web.pdf"},{"key":"e_1_3_5_16_2","first-page":"225","article-title":"Barriers to the use of basic health services among women in rural southern Egypt (upper Egypt)","volume":"75","author":"Chiang C","year":"2013","unstructured":"Chiang C, Labeeb SA, Higuchi M, et al: Barriers to the use of basic health services among women in rural southern Egypt (upper Egypt). Nagoya J Med Sci 75:225-231, 2013","journal-title":"Nagoya J Med Sci"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12071050"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14090939"},{"key":"e_1_3_5_19_2","doi-asserted-by":"crossref","unstructured":"Gupta S Howard SC Hunger SP et al: Treating childhood cancer in low- and middle-income countries in Gelband H Jha P Sankaranarayanan R et al (eds): Cancer: Disease Control Priorities Volume 3 (ed 3). 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