{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:54:37Z","timestamp":1783000477502,"version":"3.54.5"},"reference-count":28,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Buccal mucosa cancer (BMC), the most prevalent oral cancer (OC) site, is a multifactorial disease. With relatively high prevalence of periodontal diseases because of poor oral hygiene practices, oral health indicators remain an area of exploration in the Indian context for its association with BMC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>A total of 1,673 histologically confirmed cases and 1,601 frequency-matched controls from a hospital-based, multicenter case-control study was analyzed for the risk of BMC because of the oral hygiene indicators\u2014denture use, number of decayed, missing, and filled teeth, and the Decayed, Missing, Filled Teeth (DMFT) score. Logistic regression models, adjusted for potential confounders like age, sex, rural-urban status, education, and tobacco and alcohol use (duration and frequency), were used to estimate odds ratios (ORs) and 95% CI. Analysis was further stratified on tobacco chewing and smoking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              We obtained an increased risk of decayed (OR\n              <jats:sub>&gt;2 decayed teeth<\/jats:sub>\n              , 1.53; 95% CI, 1.09 to 2.16), missing teeth (OR\n              <jats:sub>&gt;2 missing teeth<\/jats:sub>\n              , 2.59; 95% CI, 1.99 to 3.37), and high DMFT scores (OR\n              <jats:sub>&gt;3 DMFT score<\/jats:sub>\n              , 2.07; 95% CI, 1.62 to 2.66). Similar results were observed on the stratified analysis. Protective effect was observed for teeth filling (OR\n              <jats:sub>&gt;2 teeth-fillings<\/jats:sub>\n              , 0.59; 95% CI, 0.34 to 1.03) and denture use (OR\n              <jats:sub>ever versus never used dentures<\/jats:sub>\n              , 0.63; 95% CI, 0.47 to 0.85).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Our findings suggest that DMFT score is associated with the risk of BMC and should be included in national oral health programs for prevention of OCs, along with other indicators of oral hygiene.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-25-00119","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T19:59:29Z","timestamp":1753300769000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Association of Decayed, Missing, Filled Teeth Score With the Risk for Buccal Mucosa Cancer, Stratified on Tobacco and Alcohol Use: A Multicenter Case-Control Study From India"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4874-488X","authenticated-orcid":true,"given":"Grace Sarah","family":"George","sequence":"first","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8119-8439","authenticated-orcid":true,"given":"Arjun","family":"Singh","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"},{"name":"Department of Head and Neck Oncology, Tata Memorial Centre, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6754-0523","authenticated-orcid":true,"given":"Romi","family":"Moirangthem","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8238-955X","authenticated-orcid":true,"given":"Aniket","family":"Patil","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4601-1465","authenticated-orcid":true,"given":"Gayathri B.","family":"Pullat","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Sagare","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-4814","authenticated-orcid":true,"given":"Manigreeva","family":"Krishnatreya","sequence":"additional","affiliation":[{"name":"Dr B. Borooah Cancer Institute\u2014Tata Memorial Centre, Guwahati, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7823-5334","authenticated-orcid":true,"given":"Aseem","family":"Mishra","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"},{"name":"Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Sonwane","sequence":"additional","affiliation":[{"name":"Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-9133","authenticated-orcid":true,"given":"Bayan","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, World Health Organisation, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2696-8899","authenticated-orcid":true,"given":"Anil","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-1342","authenticated-orcid":true,"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"},{"name":"Department of Head and Neck Oncology, Tata Memorial Centre, Mumbai, India"},{"name":"Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Dikshit","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"},{"name":"Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7072-802X","authenticated-orcid":true,"given":"Sharayu","family":"Mhatre","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute (HBNI), Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_8_2_2","volume-title":"Cancer Today","unstructured":"International Agency for Research on Cancer: Cancer Today. https:\/\/gco.iarc.who.int\/today\/"},{"key":"e_1_3_8_3_2","volume-title":"Cancer: Disease Control Priorities, Volume 3","author":"Sankaranarayanan R","year":"2015","unstructured":"Sankaranarayanan R, Ramadas K, Amarasinghe H, et al: Oral cancer: Prevention, early detection, and treatment, in Gelband H, Jha P, Sankaranarayanan R, et al (eds): Cancer: Disease Control Priorities, Volume 3 (ed 3). 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