{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T20:58:43Z","timestamp":1765832323877,"version":"3.48.0"},"reference-count":7,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Fever with neutropenia (FN) is a common complication of cancer treatment in children and is associated with high morbidity and mortality. Evidence-based clinical practice guidelines (CPGs) for FN aim to standardize care and thereby improve it, prioritize resources, and influence national policies. Despite the significant burden of childhood cancer in sub-Saharan Africa, current CPG fail to explicitly address certain conditions critical for our context. We developed a FN management CPG for pediatric cancer patients in sub-Saharan African countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The clinical guideline development process involved training of panelists (oncology specialists) in 10 sub-Saharan African countries on guideline development. The guideline was developed following the Grading of Recommendations, Assessment, Development and Evaluation approach. Question development by panelists, systematic review to evaluate evidence for itemized questions, and in-person voting for each recommendation were conducted. Classification of the decision to \u201crecommend\u201d or \u201cnot recommend\u201d and the strength of recommendation (strong versus conditional) was decided by a simple majority among (&gt;50%) the CPG panel members.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Fifty-eight respondents representing 19 countries in the region participated in the question prioritization exercise. Fifteen panelists received training in evidence synthesis and guideline development. Twenty-five recommendations and two definitions intended for practice settings in sub-Saharan Africa were developed to address the management of pediatric FN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This FN guideline developed by a multidisciplinary team incorporates regional considerations in treatment of FN and can serve as a tool for policymaking. The performance of guideline recommendations and associated outcomes should be monitored to improve FN outcomes in the region. The CPG development also highlights the need for more research efforts on the continent to generate evidence tailored to the local context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-25-00215","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T20:57:17Z","timestamp":1765832237000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Context-Informed Clinical Practice Guidelines for Fever With Neutropenia Management Among Sub-Saharan African Children With Cancer: A GRADE-Based Approach"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-3945","authenticated-orcid":true,"given":"Motunrayo","family":"Adekunle","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Lagos State University Teaching Hospital, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Majaliwa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kilimanjaro Christian Medical Center, Kilimanjaro, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-6753","authenticated-orcid":true,"given":"Tea","family":"Reljic","sequence":"additional","affiliation":[{"name":"Research Methodology and Biostatistics Core, College of Medicine Office of Research, University of South Florida, Tampa, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Workeabeba","family":"Abebe","sequence":"additional","affiliation":[{"name":"Tikur Anbessa Specialized Hospital, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0237-5626","authenticated-orcid":true,"given":"Karim","family":"Assani","sequence":"additional","affiliation":[{"name":"University of Kinshasa, Kinshasa, Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-8568","authenticated-orcid":true,"given":"Barnabas","family":"Atwiine","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thelma","family":"Ayisi","sequence":"additional","affiliation":[{"name":"Patient Representative, Accra, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5282-7833","authenticated-orcid":true,"given":"Nickhill","family":"Bhakta","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomie Jebessa","family":"Deribessa","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Improvement, Addis Ababa, Ethiopia"},{"name":"St Paul's Hospital Millenium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-1068","authenticated-orcid":true,"given":"Joyce","family":"Kambugu","sequence":"additional","affiliation":[{"name":"Uganda Cancer Institute, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincentia Lafeyoh","family":"Kifem","sequence":"additional","affiliation":[{"name":"Baptist Hospital Mutengene, South West Region, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Lubwama","sequence":"additional","affiliation":[{"name":"Makerere University College of Health Sciences, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Mamude","family":"Dinkiye","sequence":"additional","affiliation":[{"name":"St Paul's Hospital Millenium Medical College, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5908-4785","authenticated-orcid":true,"given":"Vongai","family":"Mashoko","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Childcare, Parirenyatwa Group of Hospitals, Harare, Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-9624","authenticated-orcid":true,"given":"Glenn Mbah","family":"Afungchwi","sequence":"additional","affiliation":[{"name":"Department of Nursing and Midwifery, The University of Bamenda, Bamenda, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Moreno","family":"Berrio","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Mulindwa","sequence":"additional","affiliation":[{"name":"Cancer Diseases Hospital, Lusaka, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Mutua","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Gertrude's Children's Hospital, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shauna Georgia Odongo","family":"Arao","sequence":"additional","affiliation":[{"name":"Uganda Cancer Institute, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-1334","authenticated-orcid":true,"given":"Ayomide","family":"Omotola","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, 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