{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:52:17Z","timestamp":1773960737824,"version":"3.50.1"},"reference-count":21,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are clinically significant in patients with cancer, as chemotherapy can trigger viral reactivation, leading to liver failure, treatment interruption, or death. Despite this risk, routine viral screening in patients with solid tumors remains inconsistent across institutions and guidelines. The purpose is to determine the frequency of viral screening and the prevalence of HBV, HCV, and HIV infections\u2014and to assess the rate of viral reactivation\u2014in a large cohort of newly diagnosed adult patients with cancer receiving chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS<\/jats:title>\n                    <jats:p>A retrospective, multicenter cohort study was conducted across 15 oncology centers in Turkey. Data from 15,942 adults with solid tumors receiving parenteral chemotherapy between January 2018 and December 2022 were analyzed. Patients with primary liver cancer or those receiving non-immunosuppressive therapies were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 15,942 patients (median age, 58 years [range, 16-94]; 51.4% male), hepatitis B surface antigen (HBsAg) testing was performed in 90.3%, anti-HCV in 71.7%, and anti-HIV in 64.0%. HBV infection was identified in 4.5% (n = 645), with only 42.9% receiving antiviral prophylaxis. HBV reactivation occurred in 4.0% of HBsAg-positive patients (n = 26). Anti-HCV positivity was found in 0.4% (n = 46), of whom 17.4% had detectable HCV RNA and received treatment. HIV infection was rare (0.06%; n = 6), and no cases of viral reactivation were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This large multicenter study highlights persistent gaps in viral screening and prophylaxis among patients with solid tumors. Despite lower HBV reactivation rates\u2014likely due to partial prophylaxis\u2014preventable complications still occurred. Despite increases in vaccination and prophylaxis, reactivation rates remain a significant problem. Standardized national protocols for prechemotherapy viral screening and timely antiviral therapy are essential to improve patient safety and treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-25-00234","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:59:11Z","timestamp":1773950351000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Reactivation of Hepatitis B and C in Patients Undergoing Chemotherapy for Solid Tumors"],"prefix":"10.1200","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-4142","authenticated-orcid":true,"given":"Mustafa","family":"G\u00fcrb\u00fcz","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Ba\u015fkent University Faculty of Medicine, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Tural","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ko\u00e7 University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timu\u00e7in","family":"\u00c7il","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hacer","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-5603","authenticated-orcid":true,"given":"Osman","family":"K\u00f6stek","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Marmara University Faculty of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem Nuray","family":"Sever","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medical Park Bah\u00e7elievler Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-4141","authenticated-orcid":true,"given":"\u0130mdat","family":"Ero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-1119","authenticated-orcid":true,"given":"\u0130zzet","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Acibadem Atakent Hospital, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7021-6139","authenticated-orcid":true,"given":"Mehmet Ali Nahit","family":"\u015eendur","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-7432","authenticated-orcid":true,"given":"\u00c7a\u011fatay","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Bah\u00e7e\u015fehir University Faculty of Medicine, \u0130zmir Medikalpark Hospital, \u0130zmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-7488","authenticated-orcid":true,"given":"Emre","family":"Akar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Bak\u0131rk\u00f6y Dr. Sadi Konuk 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Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-9842","authenticated-orcid":true,"given":"\u015eahin","family":"La\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ko\u00e7 University School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9522-9849","authenticated-orcid":true,"given":"Didem","family":"Ta\u015ftekin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Biruni University Faculty of Medicine, \u0130stanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcng\u00f6r","family":"Utkan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, 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