{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:08:31Z","timestamp":1775250511372,"version":"3.50.1"},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma worldwide and in Saudi Arabia. However, regional data on clinical characteristics and outcomes remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This multicenter retrospective cohort study included 516 patients age \u226514 years diagnosed with DLBCL between January 2016 and December 2023 at two tertiary hospitals in Saudi Arabia. Data on demographics, disease features, treatment, and outcomes were collected. Survival analysis was performed using Kaplan-Meier and Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The median age at diagnosis was 60.5 years, with 53% of patients younger than 65 years. Most patients (77%) had advanced-stage disease. Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone was the most commonly used first-line regimen, particularly in younger patients (95%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      62%). Complete remission rates were 74% in patients younger than 65 years and 66% in those 65 years and older (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .09). Relapse or refractory disease occurred more frequently in older patients (40%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      27%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .0019). Two-year progression-free survival was 78% in younger patients and 64% in older patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004), while 2-year overall survival (OS) was 87% and 76%, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001). Age, performance status, comorbidities,\n                      <jats:italic toggle=\"yes\">MYC<\/jats:italic>\n                      expression, and kidney involvement were significant predictors of OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study provides valuable real-world insight into the clinical landscape of DLBCL in Saudi Arabia. Overall outcomes are consistent with international data, although older age and comorbidities remain associated with poorer prognosis. As advanced therapies such as chimeric antigen receptor T-cell therapy and bispecific antibodies become more available, further improvements in survival are expected. These findings underscore the need for a national lymphoma registry and continued investment in research infrastructure to guide evidence-based, personalized care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-25-00432","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:59:14Z","timestamp":1775246354000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Outcome of Diffuse Large B-Cell Lymphoma: Real-World Data From Saudi Arabia"],"prefix":"10.1200","volume":"12","author":[{"given":"Abdullah M.","family":"Alrajhi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, AlFaisal University, Riyadh, Saudi Arabia"},{"name":"Clinical Pharmacy Department, King Fahad Medical City, Riyadh, Saudi Arabia"},{"name":"Department of Pharmacy, Oncoclinicas, Riyadh, Saudi 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Practice, College of Pharmacy, AlFaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysha","family":"Masri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, AlFaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4595-8154","authenticated-orcid":true,"given":"Arwa AlHaj","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, AlFaisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6898-0328","authenticated-orcid":true,"given":"Amal","family":"AlOtaibi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, AlFaisal University, Riyadh, Saudi 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Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9174-5803","authenticated-orcid":true,"given":"Mohsen","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia"},{"name":"King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-3256","authenticated-orcid":true,"given":"Ahmed S.","family":"Alaskar","sequence":"additional","affiliation":[{"name":"Department of Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia"},{"name":"King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi 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