{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:44:33Z","timestamp":1782938673255,"version":"3.54.5"},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Breast cancer (BC) is the most commonly diagnosed malignancy among women worldwide and the leading cause of cancer-related death in this population in Argentina. Despite its burden, Argentina lacks comprehensive epidemiologic data. In low- and middle-income countries (LMICs), acknowledging existing disparities and delays in treatment is essential for implementing cost-effective policies that optimize outcomes and reduce relapse and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>This retrospective, observational study analyzed 786 women with operable BC treated between 2017 and 2022 in two Buenos Aires institutions. Patients were stratified by health coverage: private prepaid health insurance (PPHI, n = 557) and social security (SS, n = 229). Four quality indicators were assessed: stage at diagnosis, time from anomaly detection to pathologic diagnosis and treatment initiation, and adherence to multimodal therapy. In addition, the impact on eligibility for adjuvant cyclin-dependent kinase inhibitors (CDK4\/6i) was evaluated in the hormone receptor\u2013positive\/human epidermal growth factor receptor 2\u2013negative subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Patients with PPHI were significantly more likely to be diagnosed at earlier stages (stage I: 56.7%\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      37.1%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05) and to meet WHO benchmarks for timely diagnosis (&lt;60 days) and treatment (&lt;90 days). Median time to diagnosis and treatment was notably shorter in the PPHI group (30.5\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      61 days and 76\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      126 days, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). CDK4\/6i eligibility was higher among SS patients, suggesting more advanced disease and increased treatment cost burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Disparities between Argentina's health subsystems significantly affect the BC stage at diagnosis and treatment timelines, influencing therapeutic pathways and associated costs. These findings highlight the need for targeted, system-level interventions. While further research is needed to confirm their long-term impact, such efforts may contribute to more equitable care and improved outcomes in LMICs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-25-00753","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:59:24Z","timestamp":1782935964000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Breast Cancer Care Disparities in Argentina: Diagnosis, Treatment Timeliness, and Cyclin-Dependent Kinase Inhibitor Implications"],"prefix":"10.1200","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-3494","authenticated-orcid":true,"given":"Micaela P.","family":"Rivero","sequence":"first","affiliation":[{"name":"Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danisa","family":"Fari\u00f1a","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2774-0416","authenticated-orcid":true,"given":"Francisca","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e1n, Buenos Aires, Argentina"},{"name":"Sanatorio G\u00fcemes, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Boixart","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Camargo Graffigna","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico L.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e1n, Buenos Aires, Argentina"},{"name":"Sanatorio G\u00fcemes, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"G\u00f3mez Abuin","sequence":"additional","affiliation":[{"name":"Hospital Alem\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_4_2_2","volume-title":"Estad\u00edsticas\u2013Incidencia","author":"Ministerio de Salud de la Naci\u00f3n Argentina. 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JCO Glob Oncol 10.1200\/GO.20.00566","journal-title":"JCO Glob Oncol"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030604"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/GO-25-00753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:59:38Z","timestamp":1782935978000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/GO-25-00753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1200\/GO-25-00753"],"URL":"https:\/\/doi.org\/10.1200\/go-25-00753","relation":{},"ISSN":["2687-8941"],"issn-type":[{"value":"2687-8941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2500753"}}