{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:45:29Z","timestamp":1792010729753,"version":"4.4.0"},"reference-count":44,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>In an era of rapid technological advancements, the Asia-Pacific (APAC) region stands at the forefront of health care innovation, leveraging real-world evidence (RWE) to drive transformative changes. RWE, derived from real-world data such as electronic health records and patient registries, provides actionable insights that supplement clinical trial data, thus enhancing clinical decision making and policy formulation. The utilization of RWE has become crucial, especially in addressing the diverse health care needs of the APAC region. Despite the potential, APAC faces significant challenges, including heterogeneous data collection methodologies, limited technological infrastructure, and regulatory disparities. To overcome these barriers, collaborative efforts among governments, health care institutions, and industry partners are essential. The methodology of this study involved the collaboration of a group of experts to assess the current state of RWE utilization, explore challenges and opportunities, and synthesize recommendations for harmonizing RWE practices. The APAC Oncology Drug Development Consortium Working Group recommends harmonizing data standards, fostering collaborative partnerships, and promoting policy innovations to facilitate the effective use of RWE. By focusing on these areas, APAC can enhance data quality, aiding health technology assessment, improve health care delivery and decision making, and achieve better patient outcomes. The successful integration of RWE into decision-making processes will require a unified approach to data standards, robust quality assurance measures, and a commitment to ethical data-sharing practices. As the health care landscape continues to evolve, embracing RWE offers a promising pathway to accelerate therapeutic innovations and improve public health across the region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-26-00217","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:59:08Z","timestamp":1792007948000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Leveraging Real-World Evidence to Drive Advances in Oncology Care in the Asia-Pacific Region: Recommendations From the Asia-Pacific Oncology Drug Development Consortium Working Group"],"prefix":"10.1200","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-1106","authenticated-orcid":true,"given":"Herbert H.","family":"Loong","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-8033","authenticated-orcid":true,"given":"Pankaj Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"Clinical Research Secretariat, Apollo Proton Cancer Centre, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-354X","authenticated-orcid":true,"given":"Ben","family":"Tran","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-0638","authenticated-orcid":true,"given":"Toshio","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of New Experimental Therapeutics, Early-Phase 1 Drug Development Service, Kansai Medical University Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9638-9860","authenticated-orcid":true,"given":"Pei Jye","family":"Voon","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Hospital Umum Sarawak, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9161-4918","authenticated-orcid":true,"given":"Frederic Ivan Leong","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of St La Salle, Bacolod City, Philippines"},{"name":"Department of Medicine, Section of Oncology, Corazon Locsin Montelibano Memorial Regional Hospital, Bacolod, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-8458","authenticated-orcid":true,"given":"Takafumi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-2441","authenticated-orcid":true,"given":"Daphne","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Oncology, Monash Health and Monash University, Bentleigh, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-1986","authenticated-orcid":true,"given":"K. Arnold","family":"Chan","sequence":"additional","affiliation":[{"name":"Health Data Research Center, National Taiwan University, Taipei, Taiwan"},{"name":"TriNetX, LLC, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-9389","authenticated-orcid":true,"given":"Grace L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; Therapeutics, Medical Data Analytics Centre (MDAC), The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6514-6786","authenticated-orcid":true,"given":"Daniel S.W.","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0647"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40290-022-00456-6"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/picr.picr_62_21"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0425"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-2639"},{"key":"e_1_3_7_7_2","unstructured":"Framework for FDA\u2019s real-world evidence program 2018 www.fda.gov"},{"key":"e_1_3_7_8_2","unstructured":"Reference deleted"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2474"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1609216"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0712"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0167-7"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00017-8"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.7916"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/picr.picr_193_22"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.2196\/43741"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5084"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2022.2096354"},{"key":"e_1_3_7_19_2","first-page":"6858","article-title":"What, where, and how to collect real-world data and generate real-world evidence to support drug reimbursement decision-making in Asia: A reflection into the past and A way forward","volume":"12","author":"Kc S","year":"2023","unstructured":"Kc S, Lin LW, Bayani DBS, et al: What, where, and how to collect real-world data and generate real-world evidence to support drug reimbursement decision-making in Asia: A reflection into the past and A way forward. Int J Health Pol Manag 12:6858, 2023","journal-title":"Int J Health Pol Manag"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2022.01.012"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.06.006"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4879"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1236462"},{"key":"e_1_3_7_24_2","unstructured":"Therapeutic Goods Administration: Real world evidence and patient reported outcomes in the regulatory context 2022. https:\/\/www.tga.gov.au\/real-world-evidence-rwe-and-patient-reported-outcomes-pros"},{"key":"e_1_3_7_25_2","volume-title":"DIA Glob Forum","author":"Real-World Evidence Regulatory Landscape in Asia Pacific: Australia, China, Japan, South Korea, and Taiwan","year":"2022","unstructured":"Real-World Evidence Regulatory Landscape in Asia Pacific: Australia, China, Japan, South Korea, and Taiwan. DIA Glob Forum, 2022. https:\/\/globalforum.diaglobal.org\/issue\/june-2022\/real-world-evidence-regulatory-landscape-in-asia-pacific-australia-china-japan-south-korea-and-taiwan\/"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S110339"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12650"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.02.004"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2580"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2022.100404"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-022-02162-4"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02122-4"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyac186"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-023-02334-w"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-070188"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.1350"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10071144"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-071859"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.864960"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/17588359241293393"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462320000628"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.03.013"},{"key":"e_1_3_7_43_2","unstructured":"Reference deleted"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.13585.2"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.928121"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/GO-26-00217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:59:09Z","timestamp":1792007949000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/GO-26-00217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1200\/GO-26-00217"],"URL":"https:\/\/doi.org\/10.1200\/go-26-00217","relation":{},"ISSN":["2687-8941"],"issn-type":[{"value":"2687-8941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2600217"}}