{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:12:50Z","timestamp":1789157570809,"version":"build-2803163510"},"reference-count":84,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is an aggressive, heterogeneous subtype of non-Hodgkin lymphoma with poor prognosis and limited therapeutic options. In Latin America (LATAM), management is challenged by restricted access to advanced diagnostics, higher prevalence of oncogenic viruses (Epstein-Barr virus, HTLV-1), and variable health care resources. This international consensus provides evidence-based, regionally adapted recommendations for diagnosis, staging, risk stratification, treatment, and follow-up of adult patients with PTCL-NOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A multidisciplinary panel of hematologists and oncologists from multiple LATAM countries, who are members of the\n                      <jats:italic toggle=\"yes\">Grupo de Estudio Latinoamericano de Linfoproliferativos<\/jats:italic>\n                      , used a modified Delphi process (February-July 2025). An initial questionnaire of 11 items addressed diagnostic evaluation, staging, risk stratification, first-line therapy, response assessment, consolidation with stem-cell transplantation, salvage therapy, and supportive care. Consensus was defined as \u226580% agreement on a five-point Likert scale using the RAND\/UCLA appropriateness method. Two rounds of anonymous voting and discussion incorporated cost-effectiveness and local resource constraints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Key recommendations include (1) positron emission tomography (PET)\/computed tomography (CT) as preferred staging modality (with total metabolic tumor volume for prognostication) plus mandatory bone-marrow biopsy; (2) Prognostic Index for PTCL-U as primary risk-stratification tool; (3) cyclophosphamide, doxorubicin, vincristine, etoposide, prednisone for fit patients \u226460 years with planned autologous stem-cell transplantation (ASCT), versus cyclophosphamide, doxorubicin, vincristine, and prednisone-21 otherwise; (4) brentuximab vedotin + cyclophosphamide, doxorubicin, prednisone for CD30\n                      <jats:sup>+<\/jats:sup>\n                      cases (\u226510% expression); (5) interim and end-of-treatment PET\/CT for response assessment; (6) ASCT in first complete remission; (7) early allogeneic transplantation referral for relapsed\/refractory disease; and (8) standardized immunohistochemistry\/flow cytometry panels. Resource-limited adaptations prioritize accessible strategies and encourage clinical trial participation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This LATAM-specific consensus integrates global evidence with regional realities to optimize outcomes for PTCL-NOS. Implementation should standardize care, reduce diagnostic delays, and improve equitable access to effective therapies across LATAM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-26-00265","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:59:15Z","timestamp":1789156755000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Latin American Consensus for the Diagnosis, Staging, and Treatment of Peripheral T-Cell Lymphoma Not Otherwise Specified"],"prefix":"10.1200","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-5874","authenticated-orcid":true,"given":"Henry Idrobo","family":"Quintero","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, Cl\u00ednica Central del Eje, Pereira, 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