{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:56:02Z","timestamp":1789764962561,"version":"4.0.1"},"reference-count":12,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Whether cancer is associated with worse prognosis among patients with COVID-19 is unknown. We aimed to quantify the effect (if any) of the presence as opposed to absence of cancer on important clinical outcomes of patients with COVID-19 by carrying out a systematic review and meta-analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> We systematically searched PubMed, medRxiv, COVID-19 Open Research Dataset (CORD-19), and references of relevant articles up to April 27, 2020, to identify observational studies comparing patients with versus without cancer infected with COVID-19 and to report on mortality and\/or need for admission to the intensive care unit (ICU). We calculated pooled risk ratios (RR) and 95% CIs with a random-effects model. The meta-analysis was registered with PROSPERO (CRD42020181531). <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> A total of 32 studies involving 46,499 patients (1,776 patients with cancer) with COVID-19 from Asia, Europe, and the United States were included. All-cause mortality was higher in patients with versus those without cancer (2,034 deaths; RR, 1.66; 95% CI, 1.33 to 2.07; P &lt; .0001; 8 studies with 37,807 patients). The need for ICU admission was also more likely in patients with versus without cancer (3,220 events; RR, 1.56; 95% CI, 1.31 to 1.87; P &lt; .0001; 26 studies with 15,375 patients). However, in a prespecified subgroup analysis of patients &gt; 65 years of age, all-cause mortality was comparable between those with versus without cancer (915 deaths; RR, 1.06; 95% CI, 0.79 to 1.41; P = .71; 8 studies with 5,438 patients). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> The synthesized evidence suggests that cancer is associated with worse clinical outcomes among patients with COVID-19. However, elderly patients with cancer may not be at increased risk of death when infected with COVID-19. These findings may inform discussions of clinicians with patients about prognosis and may guide health policies. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.20.00225","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T19:59:22Z","timestamp":1591646362000},"page":"799-808","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":183,"title":["Effect of Cancer on Clinical Outcomes of Patients With COVID-19: A Meta-Analysis of Patient Data"],"prefix":"10.1200","author":[{"given":"Vassilis G.","family":"Giannakoulis","sequence":"first","affiliation":[{"name":"First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Papoutsi","sequence":"additional","affiliation":[{"name":"First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias I.","family":"Siempos","sequence":"additional","affiliation":[{"name":"First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York-Presbyterian Hospital\u2013Weill Cornell Medical Center, Weill Cornell Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"B10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jinf.2020.03.019","volume":"80","author":"Wang L","year":"2020","journal-title":"J Infect"},{"key":"B16","doi-asserted-by":"crossref","first-page":"2000460","DOI":"10.2807\/1560-7917.ES.2020.25.16.2000460","volume":"25","author":"Colaneri M","year":"2020","journal-title":"Euro Surveill"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00547-2020"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"B26","doi-asserted-by":"crossref","first-page":"104378","DOI":"10.1016\/j.jcv.2020.104378","volume":"127","author":"Nikpouraghdam M","year":"2020","journal-title":"J Clin Virol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"B43","doi-asserted-by":"crossref","first-page":"e000105","DOI":"10.1136\/esmoopen-2016-000105","volume":"2","author":"Koutsoukou A","year":"2017","journal-title":"ESMO Open"},{"key":"B45","first-page":"w20246","volume":"150","author":"Spezzani V","year":"2020","journal-title":"Swiss Med Wkly"},{"key":"B46","doi-asserted-by":"crossref","first-page":"343","DOI":"10.15585\/mmwr.mm6912e2","volume":"69","author":"Bialek S","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.20.2269"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/GO.20.00225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T07:46:27Z","timestamp":1653810387000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/GO.20.00225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1200\/GO.20.00225"],"URL":"https:\/\/doi.org\/10.1200\/go.20.00225","relation":{},"ISSN":["2687-8941"],"issn-type":[{"value":"2687-8941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"2020-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}