{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:25:26Z","timestamp":1774495526787,"version":"3.50.1"},"reference-count":49,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p>In developing countries, Hodgkin lymphoma (HL) affects the young population. In Ethiopia, nearly 70% of the population are &lt; 35 years of age. Therefore, this study aimed to elucidate the age distribution, histopathologic patterns, clinical characteristics and treatment outcomes of HL in Ethiopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p>Data from clinical records of 133 consecutive patients with HL between 2014 and 2019 were reviewed and collected. Formalin-fixed paraffin-embedded tissue blocks of HL cases were collected and used for subtype classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 68.4% (91) of the patients were male; male-to-female ratio was 2.2:1. The median age was 22 years. The age distribution was 57.1% (76), 30.8% (41), and 2.3% (3) for the age groups (10-29), (30-59), and (60-69) years, respectively. Thirteen percent (12) were associated with HIV. The majority of the cases, 50.4% (67), were of the mixed-cellularity (MCCHL) subtypes and 30% (40) nodular-sclerosis (NSCCHL). Most HIV-associated cases (60%, 6) were of the MCHL subtype. The 4-year overall survival (OS) was 83.1%. The 4-year OS of early-stage patients was 100% and advanced-stage patients with low-risk (International Prognostic Score [IPS] \u2264 2) and high-risk (IPS \u2265 3) were 94.1% and 62.9%, respectively. All patients who received combined-therapy survived, whereas those who received doxorubicin, bleomycin, vinblastine, and dacarbazine only showed a 4-year OS rate of 77.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>HL affects the youngest and most productive population in Ethiopia. The treatment outcome is favorable in both HIV-associated and non\u2013HIV-associated HL. However, the study population was likely a highly selected group as the majority of the Ethiopian population do not have access to specialized care.<\/jats:p><\/jats:sec>","DOI":"10.1200\/go.20.00391","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T21:07:25Z","timestamp":1613509645000},"page":"277-288","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Characteristics and Histopathological Patterns of Hodgkin Lymphoma and Treatment Outcomes at a Tertiary Cancer Center in Ethiopia"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-3726","authenticated-orcid":false,"given":"Makka","family":"Adam","sequence":"first","affiliation":[{"name":"Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia"},{"name":"Armauer Hansen Research Institute, Addis Ababa, Ethiopia"},{"name":"Department of Oncology, Faculty of Medicine, Lund University, Lund, Sweden"},{"name":"Yirgalem Medical College, Yirgalem, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonas","family":"Bekueretsion","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Abubeker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fisihatsion","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kwiecinska","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawleigh","family":"Howe","sequence":"additional","affiliation":[{"name":"Armauer Hansen Research Institute, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyene","family":"Petros","sequence":"additional","affiliation":[{"name":"Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-6707","authenticated-orcid":false,"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amha","family":"Gebremedhin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-344"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1177\/095952873201700106"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21438"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf652"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.91752"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920215)69:4<1047::AID-CNCR2820690436>3.0.CO;2-Z"},{"key":"b7","first-page":"2","volume":"1","author":"Tefera B","year":"2016","journal-title":"J Oncol Med Pract"},{"key":"b8","volume-title":"Africa: Ethiopia","year":"2020"},{"key":"b9","volume-title":"Population and Housing Census of Ethiopia 2007: Statistical","author":"CSA","year":"2007"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"b11","volume-title":"Cancer Today (powered by GLOBOCAN 2018). 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