{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:47:37Z","timestamp":1792716457181,"version":"4.5.0"},"reference-count":49,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Survivors of childhood cancer often experience treatment-related chronic health conditions. Given its vast population, China shares a large proportion of the global childhood cancer burden. Yet, screening and treatment of late effects in survivors of childhood cancer remain underaddressed in most regions of China. This study aimed to identify high-priority late effects for harmonizing screening guidelines within the Chinese Children's Cancer Group (CCCG), as well as barriers and enablers of the implementation of surveillance recommendations in local practice. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> To establish clinical consensus, 12 expert panelists who represent major institutions within the CCCG completed a Delphi survey and participated in a focus group discussion. The survey solicited ratings of the prevalence, severity, and priority for screening of 45 late effects. Major themes identified from the focus group were analyzed using thematic analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> The Delphi survey identified eight high-priority late effects for harmonization within CCCG: osteonecrosis, osteoporosis, left ventricular dysfunction, secondary brain tumors, treatment-related myeloid leukemia, gonadal dysfunction, growth hormone deficiency, and neurocognitive deficits. The common barriers to implementing survivorship programs include lack of support and resources for clinicians to provide follow-up care. Patients were also concerned about privacy issues and lacked awareness of late effects. Many institutions also lacked rehabilitation expertise and referral pathways. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> By identifying obstacles related to the professional setting, patient behavior, and organization of care, our study identified resources and a framework for establishing collaborative strategies to facilitate follow-up care of childhood cancer survivors in China. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.20.00534","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T21:05:32Z","timestamp":1613509532000},"page":"261-276","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Identifying Priorities for Harmonizing Guidelines for the Long-Term Surveillance of Childhood Cancer Survivors in the Chinese Children Cancer Group (CCCG)"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-8938","authenticated-orcid":false,"given":"Yin Ting","family":"Cheung","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-5753","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-4044","authenticated-orcid":false,"given":"Jiaoyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Department of Hematology and Oncology, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung Wai Phillip","family":"Au-Doung","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lok Sum","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Pediatric Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Department of Paediatrics Haematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianmin","family":"Guan","sequence":"additional","affiliation":[{"name":"Division of Hematology, Children's Hospital, Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-5658","authenticated-orcid":false,"given":"Ching-Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"Department of Oncology, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6984-2407","authenticated-orcid":false,"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Oncology, St Jude Children's Research Hospital, Memphis, TN"},{"name":"Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-5758","authenticated-orcid":false,"given":"Chi-kong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong"},{"name":"Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong"},{"name":"Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2014.34.e423"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa060185"},{"key":"b3","volume-title":"From Cancer Patient to Cancer Survivor: Lost in Transition","author":"Hewitt M","year":"2006"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2013.09.004"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.032"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24445"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21445"},{"key":"b8","volume-title":"Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer Version 4","year":"2013"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.0474"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.04.021"},{"key":"b11","first-page":"250","volume":"3","author":"Lu L","year":"2015","journal-title":"Ann Transl Med"},{"key":"b12","volume-title":"Chinese Children Cancer Group","author":"Chinese Anticancer Association"},{"key":"b13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/JGO.19.11000","volume":"5","author":"Pui CH","year":"2019","journal-title":"J Glob Oncol"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316181"},{"key":"b15","volume-title":"Delphi Process: A Methodology Used for the Elicitation of Opinions of Experts","author":"Brown BB","year":"1968"},{"key":"b16","volume-title":"Challenges to Implementing a Survivorship Program"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1188\/13.ONF.575-580"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1007\/s13187-015-0848-6"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-017-0667-3"},{"key":"b20","volume-title":"2019 St Jude-VIVA-NCMC Pediatric Hematology\/Oncology Forum","author":"Pediatric Hematology\/Oncology Forum","year":"2019"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-019-00759-9"},{"key":"b23","first-page":"567","volume":"2","author":"Rahman AM","year":"2007","journal-title":"Int J Nanomedicine"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2015.11.012"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31610-0"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2016.1204012"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2016.1196732"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000095"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23809"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.7528"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx224"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.5334\/ijic.3954"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0103"},{"key":"b34","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30570-8"},{"key":"b36","volume-title":"Summary of Cancer Treatment. The Children's Oncology Group"},{"key":"b37","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30122-7"},{"key":"b38","author":"Li L","journal-title":"Radiology"},{"key":"b39","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2284-y"},{"key":"b40","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00042-X"},{"key":"b41","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-017-0644-x"},{"key":"b42","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.9812"},{"key":"b43","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5215"},{"key":"b44","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-13-211"},{"key":"b45","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-017-0607-2"},{"key":"b46","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0805-T"},{"key":"b47","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.1474"},{"key":"b48","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.03.12"},{"key":"b49","first-page":"422","volume":"7","author":"Frazelle ML","year":"2016","journal-title":"J Adv Pract Oncol"},{"key":"b50","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/jpepsy\/jss064","volume":"37","author":"George SM","year":"2012","journal-title":"J Pediatr Psychol"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/GO.20.00534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:04:53Z","timestamp":1653811493000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/GO.20.00534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1200\/GO.20.00534"],"URL":"https:\/\/doi.org\/10.1200\/go.20.00534","relation":{},"ISSN":["2687-8941"],"issn-type":[{"value":"2687-8941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2020-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}