{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T13:14:56Z","timestamp":1769001296212,"version":"3.49.0"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> People living with HIV (PLWH) experience increased risk of Hodgkin lymphoma (HL) despite effective initiation of antiretroviral therapy (ART). In high-income countries, outcomes following HIV HL have been reported to be non-differential, or inferior for PLWH. We sought to assess the effect of HIV on HL survival in Botswana, an African country with a generalized HIV epidemic and high ART coverage, to describe a context more reflective of global HIV populations. <\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p> In the Thabatse Cancer Cohort, consenting participants initiating treatment for HL at one of four cancer centers in Botswana were enrolled from 2010 to 2020. Patients were followed quarterly for up to 5 years. The impact of HIV on survival following treatment initiation was assessed using an inverse probability\u2013weighted Cox marginal structural model adjusted for age, performance status, and disease stage. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Seventy-eight new HL cases were enrolled, 47 (60%) were PLWH and 31 (40%) were HIV-uninfected. Baseline characteristics were similar between groups. The majority (61%) of patients presented with regional disease (stage I or II) with no statistically significant difference by HIV status ( P = .38). Nearly all (87%) PLWH participants were on ART before their HL diagnosis (median ART duration 42 months), and median CD4 count was 413 cells\/\u03bcL (interquartile range 253-691). Survival, in unadjusted analyses, was lower among patients without HIV compared with PLWH (log rank P = .021). In adjusted analysis, HIV infection was not significantly associated with survival in inverse probability\u2013weighted Cox model (hazard ratio 0.43; 95% CI, 0.16 to 1.16; P = .094). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> In this cohort of patients treated for HL in Botswana, survival in PLWH (87% on long-standing ART) was at least as good as in individuals without HIV. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.21.00163","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T20:59:21Z","timestamp":1642107561000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":13,"title":["HIV and Hodgkin Lymphoma Survival: A Prospective Study in Botswana"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-4854","authenticated-orcid":false,"given":"Kaelo","family":"Moahi","sequence":"first","affiliation":[{"name":"Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"},{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-3722","authenticated-orcid":false,"given":"Tlotlo","family":"Ralefala","sequence":"additional","affiliation":[{"name":"Princess Marina Hospital, Ministry of Health and Wellness, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Nkele","sequence":"additional","affiliation":[{"name":"Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0894-2196","authenticated-orcid":false,"given":"Scott","family":"Triedman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Warren Alpert Medical School, Providence, RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-4854","authenticated-orcid":false,"given":"Aliyah","family":"Sohani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital, Boston, MA"},{"name":"Department of Pathology, Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-0759","authenticated-orcid":false,"given":"Zola","family":"Musimar","sequence":"additional","affiliation":[{"name":"Princess Marina Hospital, Ministry of Health and Wellness, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-0350","authenticated-orcid":false,"given":"Jason","family":"Efstathiou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-1603","authenticated-orcid":false,"given":"Philipe","family":"Armand","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology\/Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-9716","authenticated-orcid":false,"given":"Shahin","family":"Lockman","sequence":"additional","affiliation":[{"name":"Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana"},{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. 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