{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:31:59Z","timestamp":1772803919829,"version":"3.50.1"},"reference-count":45,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p>Estrogen receptors (ERs), progesterone receptors (PRs), and human epidermal growth factor receptor 2 (HER2) are the mainstay of breast cancer management, and their prevalence rates vary among different populations possibly related to ethnic\/genetic and\/or socioeconomic status. In a previous study conducted at the King Hussein Cancer Center (published 2006), Jordan ER\/PR\/HER2 rates for patients diagnosed in 2003-2004 were 50.8%\/57.5%\/17.5%, respectively. The aim of this study is to revisit the prevalence rates to see if they have changed over the years with changing socioeconomic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p>We retrieved clinicopathologic data of all patients (1,185) diagnosed with breast cancer during 2018. The data included age, histologic type, grade, and ER\/PR\/HER2 status as determined by immunohistochemistry and\/or fluorescence in situ hybridization for HER2.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mean age of patients was 52 (median = 51, range = 25-92) years, and the majority (73.2%) had invasive carcinoma of no special type. ER\/PR\/HER2 were 77.0%\/72.4%.\/23.8%, respectively. Triple-negative breast cancers were 10.1%. In comparison with previous results of 2006, the changes are statistically significant. Similar changes were seen in other Middle Eastern populations. The current rates are close to those of Western populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Rates of ER\/PR\/HER2 expression have significantly changed and are close to those of Western populations for ER\/PR. We propose that such changes are secondary to the adoption of a westernized lifestyle and socioeconomic changes.<\/jats:p><\/jats:sec>","DOI":"10.1200\/go.21.00359","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T19:59:22Z","timestamp":1650311962000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Changing Trends in Estrogen Receptors\/Progesterone Receptors\/Human Epidermal Growth Factor Receptor 2 Prevalence Rates Among Jordanian Patients With Breast Cancer Over the Years"],"prefix":"10.1200","author":[{"given":"Anas M.","family":"Alsughayer","sequence":"first","affiliation":[{"name":"King Hussein Cancer Center, Amman, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara Z.","family":"Dabbagh","sequence":"additional","affiliation":[{"name":"King Hussein Cancer Center, Amman, 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