{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:08:37Z","timestamp":1788390517802,"version":"build-2803163510"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Kaposi's sarcoma (KS) is a multifocal angioproliferative disease. In Peru, the implementation of the highly active antiretroviral treatment (HAART) program was in 2005, the model for treating patients with HIV-positive KS shifted to a potential cure. In this study, we aim to compare clinicopathological characteristics and prognostic factors associated with outcomes in patients with HIV-positive KS. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> We developed a retrospective cohort study that includes patients with HIV\/AIDS and KS seen in the Instituto Nacional de Enfermedades Neoplasicas between 1987 and 2017. Patients were divided into two groups according to the implementation of HAART in our country: the non-HAART group and those treated with HAART after 2005. Multivariate analysis for overall survival (OS) was performed with the Cox proportional hazard regression model. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> There was a greater visceral compromise and more extensive oral cavity involvement in the non-HAART group (60% 31.7%, P &lt; .01). Regarding the immune status, there was a significant difference from the CD4 count at 1-year follow-up (73 v 335, P = .01). The CD4\/CD8 rate were significant different before QT (0.23 v 0.13, P = .01) and at 1-year follow-up (0.12 v 0.32, P = .03.). The estimated 5-year OS rate was significantly lower ( P = .0001) for the non-HAART group (41.7%; 95% CI, 25.9 to 56.9) compared with the HAART group (79.3%; 95% CI, 66.8 to 87.5). In the multivariate model for OS, full-HAART regimen and previous diagnosis of HIV\/AIDS ( P &lt; .01) were significantly associated with longer survival. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Clinical and demographic characteristics of our patients are compatible with the literature, but we report a higher rate of gastrointestinal involvement. Furthermore, our findings provide evidence for the importance of HAART and its ability to reduce KS-related mortality. <\/jats:p><\/jats:sec>","DOI":"10.1200\/go.21.00379","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T19:59:25Z","timestamp":1655841565000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopathological Features and Mortality in Patients With Kaposi Sarcoma and HIV: A Retrospective Analysis of a Thirty-Year Study From a Peruvian Oncologic Center"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-7566","authenticated-orcid":false,"given":"Luis E.","family":"Cuellar","sequence":"first","affiliation":[{"name":"Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru"},{"name":"Facultad de Medicina Hip\u00f3lito Unanue, Universidad Nacional Federico Villarreal, Lima, 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